NEUROFIBRILLARY DEGENERATION AND NEURONAL LOSS IN ALZHEIMERS-DISEASE
NEUROFIBRILLARY DEGENERATION AND NEURONAL LOSS IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0197-4580(89)90007-9
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发表时间：
1989-11-01
影响因子：
4.2
通讯作者：
HAUSER, DL
中科院分区：
文献类型：
--
作者：
BONDAREFF, W;MOUNTJOY, CQ;HAUSER, DL
阿尔茨海默病S病的神经元丢失，尤其是大脑皮层和海马区的神经元丢失，似乎与神经原纤维变性过程密切相关。在某些非皮质核团中，神经元的丢失似乎不依赖于神经原纤维缠结的形成。在同一组神经元中，对五个脑区的神经纤维缠结和神经元进行了计数。在蓝斑和基底核中，缠结具有疏松或球状结构，与神经元数量的相关性不显著。在大脑皮层和海马区，缠结更密集，通常呈火焰样外观，它们与神经元数量的相关性显著。本文报道的缠结和非皮质神经元之间的关系表明，缠结的出现并不一定预示着阿尔茨海默病S病中神经元的死亡。可以合理地预计，这些关系取决于阿尔茨海默病S病的临床异质性、大脑中的区域差异和/或神经原纤维缠结的大分子组成。
Neuronal loss in Alzheimer''s disease, especially in cerebral cortex and hippocampus, appears closely associated with the process of neurofibrillary degeneration. In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles. Neurofibrillary tangles and neurons were counted in the same populations of neurons in five brain regions. In the locus ceruleus and nucleus basalis, where tangles have a loose or globose structure, correlations with neuronal counts were not significant. In cerebral cortex and hippocampus, tangles have a more dense and often a flame-like appearance and their correlations with neuronal counts were significant. The relationships between tangles and noncortical neurons reported here suggest that the appearance of tangles does not necessarily herald the demise of a neuron in Alzheimer''s disease. It can be reasonably anticipated that these relationships depend upon the clinical heterogeneity of Alzheimer''s disease, regional differences in the brain and/or the macromolecular composition of neurofibrillary tangles.