The TRI101 story: engineering wheat and barley to resist Fusarium head blight
The TRI101 story: engineering wheat and barley to resist Fusarium head blight
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DOI：
10.3920/wmj2008.x004
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发表时间：
2008-02-01
影响因子：
2
通讯作者：
Alexander, N. J.
中科院分区：
文献类型：
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作者：
Alexander, N. J.
赤霉病（Fusarium head blight，FHB）是由禾谷镰刀菌（Fusarium graminearum）引起的小麦和大麦的主要病害。自1993年以来，FHB疫情一直在增加，并对种植者和种子行业造成了严重的经济损失。沿着产量降低，霉菌毒素在发霉谷物中的存在构成谷物工业的主要问题。这些霉菌毒素在摄入后对人类和动物造成健康危害。这些真菌毒素的急性植物毒性及其在植物组织中的发生与其在植物病害的发病机理和产生中的作用相关。将Fusarium sporotrichioides Tri101基因（一种降低多孢霉素毒性的基因）整合到转基因植物中，可以降低疾病水平，从而证明通过引入毒素修饰基因可以降低小粒中FHB的严重程度和脱氧雪腐镰刀菌烯醇（DON）的积累。
Fusarium head blight (FHB), caused primarily by Fusarium graminearum, is a major disease of wheat and barley in the United States and Canada. FHB epidemics have been on the increase since 1993 and have caused severe monetary damage for the growers and seed industry. Along with reduced yields, the presence of mycotoxins in moldy grain constitutes a major problem for the grain industry. These mycotoxins pose health hazards to humans and animals upon ingestion. The acute phytotoxicity of these mycotoxins and their occurrence in plant tissues correlates with their role in pathogenesis and the production of plant disease. Transgenic plants incorporating the Fusarium sporotrichioides Tri101 gene, a gene that reduces toxicity of trichothecenes, have reduced levels of disease, thus demonstrating that FHB severity and deoxynivalenol (DON) accumulation can be reduced in small grains by the introduction of a toxin-modification gene.