Influence of skin type, race, sex, and anatomic location on epidermal barrier function
Influence of skin type, race, sex, and anatomic location on epidermal barrier function
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DOI：
10.1016/j.clindermatol.2011.08.013
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Fluhr, Joachim W.
中科院分区：
文献类型：
--
作者：
Darlenski, Razvigor;Fluhr, Joachim W.
完整的皮肤代表了对来自生物体的水、蛋白质和血浆组分的不受控制的损失的屏障。由于其结构复杂，具有主要层角质层的表皮屏障是外源性物质渗透皮肤的限速单位。表皮屏障不是一个静止的结构。表皮的不同功能的状态可以通过评估特定的生物物理参数，如经表皮水分流失，角质层水合作用，和皮肤表面pH值进行监测。变量源自个人以及外源性因素对表皮屏障参数有重要影响。(C)2012 Elsevier Inc. All rights reserved.
The intact skin represents a barrier to the uncontrolled loss of water, proteins, and plasma components from the organism. Owing to its complex structure, the epidermal barrier with its major layer, the stratum corneum, is the rate-limiting unit for the penetration of exogenous substances through the skin. The epidermal barrier is not a static structure. The status of different functions of the epidermis can be monitored by assessing specific biophysical parameters such as transepidermal water loss, stratum corneum hydration, and skin surface pH. Variables originating from the individual as well as exogenous factors have an important influence on the epidermal barrier parameters. (C) 2012 Elsevier Inc. All rights reserved.