Inflammation and Cancer
Inflammation and Cancer
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DOI：
10.1002/9781118468869.ch4
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
P. Beatty;Sandra Cascio;Olivera J. Finn
中科院分区：
文献类型：
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作者：
P. Beatty;Sandra Cascio;Olivera J. Finn
炎症和癌症之间的联系早在1863年就由Rudolf Virchow(图5.1)(Virchow 1863)发现，他首先描述了肿瘤组织中白细胞的存在(Balkwill和Mantovani 2001)。受慢性炎症病理影响的个体患癌症的风险增加，因为它们导致促炎细胞因子的释放，为肿瘤进展和转移创造有利的微环境(Balkwill等人)。2005)。例子包括肝癌的乙型和丙型肝炎病毒感染；宫颈癌的乳头状瘤病毒感染；细菌感染，如胃癌或淋巴瘤的幽门螺杆菌感染；寄生虫，如膀胱癌的血吸虫。幽门螺杆菌感染可导致幽门螺杆菌反应性T细胞的形成，进而引起多克隆B细胞的增殖。在一些患者中，病毒整合会导致染色体的二次重排，包括可能含有未知抑制基因的多重缺失。
The association between inflammation and cancer was discovered as early as 1863 by Rudolf Virchow (Fig. 5.1) (Virchow 1863), who first described the presence of a leukocyte infiltrate in tumor tissues (Balkwill and Mantovani 2001). Individuals affected by chronic inflammatory pathologies have increased risk of cancer development, since they lead to the release of proinflammatory cytokines, creating a favourable microenvironment for tumor progression and metastasis (Balkwill et al. 2005). Examples include viral infection with hepatitis B and C for liver cancer; papilloma virus for cervix carcinoma; bacterial infections, such as Helicobacter pylori for gastric cancer or lymphoma; parasites, such as Schistosoma for bladder cancer. It is thought that Helicobacter pylori infection leads to the formation of Helicobacter pylori reactive T cells, which in turn cause polyclonal B-cell proliferation. In some patients viral integrations causes secondary rearrangements of chromosomes, including multiple deletions that may harbor unknown suppressor genes.