An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa
An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa
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DOI：
10.1073/pnas.262658899
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发表时间：
2002-12-24
影响因子：
11.1
通讯作者：
Schüttler, HB
中科院分区：
文献类型：
--
作者：
Battogtokh, D;Asch, DK;Schüttler, HB
提出了粗神经孢子虫奎宁酸（qa）基因簇调控的化学反应网络。开发了一种高效的蒙特卡罗方法，用于遍历可能的化学反应网络的参数空间，以识别具有与RNA和蛋白质谱数据一致的速率常数的确定性动力学模型的集合。该方法成功地鉴定了一个模型集合，拟合了qa基因簇上可用的RNA分析数据。
A chemical reaction network for the regulation of the quinic acid (qa) gene cluster of Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the parameter space of possible chemical reaction networks is developed to identify an ensemble of deterministic kinetics models with rate constants consistent with RNA and protein profiling data. This method was successful in identifying a model ensemble fitting available RNA profiling data on the qa gene cluster.