Occupation and bladder cancer in a hospital-based case-control study in Spain
Occupation and bladder cancer in a hospital-based case-control study in Spain
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DOI：
10.1136/oem.2007.035816
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发表时间：
2008-05-01
影响因子：
4.9
通讯作者：
Dosemeci, M.
中科院分区：
文献类型：
--
作者：
Samanic, C. M.;Kogevinas, M.;Dosemeci, M.
目的：在西班牙进行的一项基于医院的病例对照研究中，我们调查了职业与膀胱癌之间的关系。方法：选取1998年6月至2000年9月西班牙18家医院的1219例膀胱移行细胞癌患者和1271例对照组，提供其一生职业史、吸烟习惯、病史及其他因素的详细资料。我们使用无条件逻辑回归计算每个职业和行业的比值比（OR）和95%置信区间（CI），调整了年龄、医院区域、吸烟时间和膀胱癌高危职业的就业情况。结果：在印刷业从事机器操作的男性（OR为5.4；95% CI为1.6至17.7）、在运输设备行业从事的男性（OR为1.6；95% CI为1.1至2.6）、在电气/燃气/卫生服务行业工作10年的男性（OR为3.9；95% CI为1.5至10.4）以及在酒店和其他住宿行业工作的男性（OR为3.1；95% CI为1.3至7.3）中，观察到统计学上显著增加的风险。从事各种机械和修理工作的男性（OR 2.0; 95% CI 1.1至3.6）和生产职业的主管（OR 2.1; 95% CI 1.2至3.6）患膀胱癌的风险也较高。男性农民以及从事农作物和畜牧业生产的人患膀胱癌的风险降低。我们没有发现职业或行业与女性膀胱癌风险之间的显著关联。结论：我们没有观察到许多被认定为先验高风险职业的膀胱癌风险过高。检查更详细的工作经历信息应该有助于澄清这些联系。
Objectives: We investigated the association between occupation and bladder cancer in a hospital-based case control study conducted in Spain.Methods: 1219 patients with transitional cell carcinoma of the urinary bladder and 1271 controls selected from 18 hospitals in Spain between June 1998 and September 2000 provided detailed information on life-time occupational history, smoking habits, medical history, and other factors. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for each occupation and industry, adjusting for age, hospital region, smoking duration, and employment in a high-risk occupation for bladder cancer.Results: Statistically significant increased risks were observed among men employed as machine operators in the printing industry (OR 5.4; 95% CI 1.6 to 17.7), among men employed in the transportation equipment industry (OR 1.6; 95% CI 1.1 to 2.6) and among those who had worked for >= 10 years in the electrical/gas/sanitary services (OR 3.9; 95% CI 1.5 to 10.4) and in hotels and other lodgings (OR 3.1; 95% CI 1.3 to 7.3). Men who worked as miscellaneous mechanics and repairers ( OR 2.0; 95% CI 1.1 to 3.6) and as supervisors in production occupations (OR 2.1; 95% CI 1.2 to 3.6) also had excess risks for bladder cancer. Male farmers and those who worked in crop and livestock production had decreased risks for bladder cancer. We found no significant associations between occupation or industry and bladder cancer risk among women.Conclusions: We did not observe excess bladder cancer risk for many of the occupations identified as being a priori at high risk. Examination of more detailed job exposure information should help clarify these associations.