Metallothionein in human lung carcinoma.
Metallothionein in human lung carcinoma.
复制标题
人肺癌中的金属硫蛋白。
DOI：
10.1016/0304-3835(93)90196-g
复制
发表时间：
1993
期刊：
影响因子：
9.7
通讯作者：
Vacek,PM
中科院分区：
文献类型：
--
作者：
Hart,BA;Voss,GW;Vacek,PM
11对手术切除的肺癌和相应的非肿瘤肺组织的金属硫蛋白（MT）和金属含量（镉和铜）的血红素/109镉结合试验和原子吸收光谱法，分别进行了评估。从51至79岁的患者获得的组织样品包括六种腺癌、两种小细胞癌、一种混合细胞癌、一种鳞状细胞癌和一种非原发性来源的癌（即，黑色素瘤）。配对检验显示，与非恶性肺组织相比，肺肿瘤组织中的金属硫蛋白和铜浓度显著升高。铜是与10 kDa的MT部分在肺肿瘤，而镉是主要的金属结合到MT从非肿瘤性肺组织的主要金属。由于铜硫蛋白也被称为是在胎儿肺组织中升高，MT可能代表一种肿瘤发育产物，这是有用的生物标志物，用于肺癌的早期检测的可能性存在。
Eleven pairs of surgically resected lung cancers and corresponding non-neoplastic lung tissue were evaluated for metallothionein (MT) and metal content (cadmium and copper) by the heme/109Cd binding assay and atomic absorption spectroscopy, respectively. Tissue samples, obtained from patients ranging in age from 51 to 79, included six adenocarcinomas, two small cell carcinomas, one mixed cell carcinoma, one squamous cell carcinoma, and one carcinoma of non-primary origin (i.e., melanoma). Pairedt-tests showed that metallothionein and copper concentrations in lung tumor tissue were significantly elevated when compared to non-malignant lung tissue. Cu was the major metal associated with the 10 kDa MT fraction in lung tumors whereas Cd was the primary metal bound to MT from nonneoplastic lung tissue. Since Cu-thionein is also known to be elevated in fetal lung tissue, the possibility exists that MT might represent an oncodevelopmental product which is useful as a biomarker for the early detection of lung carcinoma.