ANTI-IL-10 TREATMENT DOES NOT BLOCK EITHER THE INDUCTION OR THE MAINTENANCE OF ORALLY INDUCED TOLERANCE TO OVA
ANTI-IL-10 TREATMENT DOES NOT BLOCK EITHER THE INDUCTION OR THE MAINTENANCE OF ORALLY INDUCED TOLERANCE TO OVA
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DOI：
10.1111/j.1365-3083.1995.tb03573.x
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发表时间：
1995-04-01
影响因子：
3.7
通讯作者：
MENGEL, J
中科院分区：
文献类型：
--
作者：
AROEIRA, LS;CARDILLO, F;MENGEL, J
在此，我们评估了IL-10在诱导和维持口服耐受中的作用。结果表明：(1)单抗抗IL-10可诱导小鼠对OVA的口服耐受；(2)抗IL-10处理不能逆转口服耐受小鼠T细胞增殖反应的体外阻断；(3)抗IL-10不能打破口服诱导的耐受。综上所述，这些结果表明，IL-10不是建立和维持口服耐受的基本细胞因子。
Herein, the role of IL-10 in the induction and maintenance of oral tolerance was evaluated. The results show that: (1) mice treated with MoAb anti-IL-10 are permissive to the induction of oral tolerance to OVA; (2) anti-IL-10 treatment did not reverse the in vitro blocking of T cell proliferative response found in orally-tolerized mice; and (3) orally-induced tolerance could not be broken by anti-IL-10 treatment. Taken together, these results suggest that IL-10 is not a fundamental cytokine for the establishment and maintenance of oral tolerance.