Detection of Epstein‐Barr virus DNA in American Burkitt's lymphoma
Detection of Epstein‐Barr virus DNA in American Burkitt's lymphoma
复制标题
美国伯基特淋巴瘤中 Epstein-Barr 病毒 DNA 的检测
DOI：
10.1002/ijc.2910170603
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发表时间：
1976
影响因子：
6.4
通讯作者：
W. Henle
中科院分区：
文献类型：
--
作者：
J. Ziegler;M. Andersson;G. Klein;W. Henle
对20例美国伯基特淋巴瘤（BL）患者进行了血清学和生化研究，以检测与Epstein巴尔病毒（EBV）的相关性。遇到了广泛的抗体反应性。5名患者的血清学特征与非洲BL患者相似：其中1名或2名患者的肿瘤中携带EBV-DNA。15名患者的EBV抗体水平较低或不存在：其中10名患者的肿瘤缺乏EBV-DNA的证据。在这一系列研究中发现，EBV病毒衣壳抗原（VCA）抗体升高（≥1：80）与预后良好之间存在无法解释的相关性;这一预后观察结果需要进一步证实。因此，似乎EBV相关BL与肿瘤的地方性成反比。EB病毒在BL中的病因作用仍然是推测性的。
Twenty American patients with Burkitt's lymphoma (BL) were studied serologically and biochemically to detect an association with Epstein‐Barr virus (EBV). A wide range of antibody reactivities was encountered. Five patients had serorogical profiles similar to those of African patients with BL: one and possibly two of these patients harbored EBV‐DNA in their tumors. Fifteen patients had low or absent antibody to EBV: tumors from 10 of these patients lacked evidence of EBV‐DNA. An unexplained association between elevated antibody (≥1:80) to EBV virus capsid antigen (VCA) and a favorable prognosis was noted in this series; this prognostic observation requires further substantiation. Thus, it appears that EBV‐associated BL is inversely proportional to tumor endemicity. An etiological role for EBV in BL remains speculative.