Three Decades of Chloride Intracellular Channel Proteins: From Organelle to Organ Physiology.
Three Decades of Chloride Intracellular Channel Proteins: From Organelle to Organ Physiology.
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DOI：
10.1002/cpph.36
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发表时间：
2018-03
影响因子：
--
通讯作者：
Singh H
中科院分区：
文献类型：
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作者：
Gururaja Rao S;Ponnalagu D;Patel NJ;Singh H
细胞内细胞器是膜结构，对于维持细胞生理学和细胞整体健康至关重要。为了维持细胞功能，细胞内细胞器需要严格调节其离子稳态。离子浓度的任何不平衡都会破坏能量产生（线粒体）、蛋白质降解（溶酶体）、DNA 复制（细胞核）或细胞信号传导（内质网）。离子稳态对于细胞内细胞器的体积调节也很重要，并且由阳离子和阴离子通道以及转运蛋白维持。主要定位于细胞内膜的离子通道的主要类别之一是氯离子通道蛋白（CLIC）。它们是非经典离子通道，在哺乳动物中具有六种同源物，以可溶性或整合膜蛋白形式存在，具有酶和通道的双重功能。在本概述中，我们简要介绍了 CLIC，并总结了有关其定位、生物物理特性和生理作用的最新信息。
Intracellular organelles are membranous structures, central for maintaining cellular physiology and the overall health of the cell. To maintain cellular function, intracellular organelles are required to tightly regulate their ionic homeostasis. Any imbalance in ionic concentrations can disrupt energy production (mitochondria), protein degradation (lysosomes), DNA replication (nucleus) or cellular signaling (endoplasmic reticulum). Ionic homeostasis is also important for volume regulation of intracellular organelles and is maintained by cation and anion channels as well as transporters. One of the major classes of ion channels predominantly localized to intracellular membranes is chloride intracellular channel proteins (CLICs). They are non-canonical ion channels with six homologs in mammals, existing as either soluble or integral membrane protein forms, with dual functions as enzymes and channels. In this overview, we have provided a brief introduction to CLICs, and also summarized recent information on their localization, biophysical properties, and physiological roles.