METHOD FOR THE SYNTHESIS OF BRIDGED INDOLE ALKALOIDS - ADDITION OF CARBON NUCLEOPHILES TO N-ALKYLPYRIDINIUM SALTS
METHOD FOR THE SYNTHESIS OF BRIDGED INDOLE ALKALOIDS - ADDITION OF CARBON NUCLEOPHILES TO N-ALKYLPYRIDINIUM SALTS
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DOI：
10.1055/s-1995-5007
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发表时间：
1995-06-01
期刊：
影响因子：
2
通讯作者：
BENNASAR, ML
中科院分区：
文献类型：
--
作者：
BOSCH, J;BENNASAR, ML
基于亲核加成的稳定的碳亲核试剂的N-烷基吡啶盐的方法构成了一个强大的工具，用于合成属于各种结构类型的桥连吲哚生物碱，无论是四环（如长春新碱和ervitsine）或五环，在后一种情况下，关闭后的色胺链上的吲哚环上的环化。
The methodology based on the nucleophilic addition of stabilized carbon nucleophiles to N-alkylpyridinium salts constitutes a powerful tool for the synthesis of bridged indole alkaloids belonging to a variety of structural types, either tetracyclic (as vinoxine and ervitsine) or pentacyclic, in the latter case after closure of the tryptamine chain by cyclization upon the indole ring.