Entorhinal theta phase precession sculpts dentate gyrus place fields
Entorhinal theta phase precession sculpts dentate gyrus place fields
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DOI：
10.1002/hipo.20450
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发表时间：
2008-01-01
期刊：
影响因子：
3.5
通讯作者：
Yamaguchi, Yoko
中科院分区：
文献类型：
--
作者：
Molter, Colin;Yamaguchi, Yoko
众所周知，海马体促进记忆形成和空间表征，并且海马位置细胞建立空间表征，并根据“θ相位进动”调节放电活动。阐明这些空间和时间活动如何相互作用以处理信息对于更连贯地理解海马体的工作方式至关重要。最近，据报道，第二层内嗅皮层细胞介导位于海马门的齿状回 (DG) 的大部分皮层输入，根据网格状模式随着 θ 相进动放电。在这里，我们假设内嗅网格神经元随着 θ 相位进动发射的时间代码提供了齿状神经元输入整合的选择性，以支持位置场的出现。我们的大规模网络模型分析表明，通过假设齿状神经元的重合检测特性，网格场可以可靠地转换以将场放置在新的环境中。此外，可以获得与已知的实验观察一致的连续环境体验中的位置场的全局重新映射。这些发现表明时间编码在内嗅海马系统中的空间计算中发挥着关键作用。 (C) 2008 Wiley-Liss, Inc.
It is known that the hippocampus facilitates memory formation and spatial representation and that hippocampal place cells establish spatial representations with firing activity modulated in terms of 'theta phase precession'. Clarifying how these spatial and temporal activities interact to process information is essential for a more coherent understanding of the way the hippocampus works. Recently, it has been reported that layer II entorhinal cortical cells, which mediate the majority of the cortical inputs to the dentate gyrus (DG), located at the gate of the hippocampus, fire with theta phase precession according to a grid-like pattern. Here we hypothesize that the temporal code of entorhinal grid neurons firing with theta phase precession provides selectivity in input integration of dentate neurons to support the emergence of place fields. Our large-scale network model analyses demonstrated that, by assuming coincidence detection properties of dentate neurons, grid fields are reliably transformed to place fields in a novel environment. Furthermore, global remapping of place fields in sequential experiences of environments can be obtained in agreement with known experimental observation. These findings indicate a critical role of temporal coding for space computation in the entorhinal-hippocampal system. (C) 2008 Wiley-Liss, Inc.