Reply to "The insular cortex and QTc interval in HIV+ and HIV- individuals: Is there an effect of sympathetic nervous system activity?"
Reply to "The insular cortex and QTc interval in HIV+ and HIV- individuals: Is there an effect of sympathetic nervous system activity?"
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回复“HIV 和 HIV-个体的岛叶皮质和 QTc 间期：交感神经系统活动是否有影响？”
DOI：
10.1016/j.clinph.2017.10.017
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kallianpur,KalpanaJ
中科院分区：
文献类型：
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作者：
McIntosh,RogerC;Chow,DominicC;Lum,CoreyJ;Shikuma,CeciliaM;Kallianpur,KalpanaJ
永井等人的通信。（2018）首先认为，我们发现左前额叶（Ia）和腹内侧前额叶皮质（VMPFC）之间的连接性更强，QTc间期更短（McIntosh等人，2017）是违反直觉的，因为狗模型的交感神经抑制QT间期延长。在我们对我们的发现提供另一种解释之前，我们首先应该强调QTc和功能性大脑连接数据是彼此独立收集的，因此排除了任何直接因果关系的推断。事实上，左Ia与副交感神经调节有关，然而，该结构在心脏内感受性意识中也起着独特的作用（Oppenheimer和Cechetto，2016）。考虑到报告的静息状态功能连接（rsFC）的测量反映了神经组件之间的依赖性特征样模式，我们提供了一个谨慎的解释增加左Ia连接VMPFC作为一种模式的反调节神经反应的高心脏收缩性短QTc间期指示。正如永井和同事们提到的，传入和传出信号在整个中央
The correspondence by Nagai et al.(2018) first contends that our finding of greater connectivity between left anterior insula (Ia) and ventromedial prefrontal cortex (VMPFC) with shorter QTc interval (McIntosh et al., 2017) is counter-intuitive given the dog model of sympathetic inhibition on QT prolongation. Before we provide an alternate interpretation of our findings we should first emphasize QTc and functional brain connectivity data were collected independent of each other, thus precluding any direct inference of causality.Indeed, the left Ia is implicated in parasympathetic regulation, however, this structure also plays a unique role in cardiac interoceptive awareness (Oppenheimer and Cechetto, 2016). Considering that the reported measure of resting state functional connectivity (rsFC) reflects trait-like patterns of dependence amongst neural assemblies we offer a cautious interpretation of the increased left Ia connectivity with VMPFC as a pattern of counterregulatory neural response to the high cardiac contractility indicative of short QTc interval. As Nagai and colleagues alluded afferent and efferent signaling throughout the Central