Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain.
Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain.
复制标题
DOI：
10.1016/j.bbrc.2009.05.133
复制
发表时间：
2009-08-28
影响因子：
3.1
通讯作者：
Sah, Renu
中科院分区：
文献类型：
--
作者：
McGuire, Jennifer;Herman, James P.;Ghosal, Sriparna;Eaton, Katherine;Sallee, Floyd R.;Sah, Renu
The T-cell death-associated gene 8 (TDAG8) is a pH-sensing GPCR with a reported immune-specific expression profile. Here, we demonstrate pH-induced activation of TDAG8 receptor cloned from rodent brain (rTDAG8). Cloned rTDAG8 transcript showed 88–95% homology with human and mouse transcripts of lymphoid origin. RT-PCR revealed high expression of TDAG8 in forebrain limbic regions. Extracellular acidification induced significantly elevated intracellular cyclic AMP, and phosphorylated CREB in TDAG8 expressing cells. Acidification-induced LDH release was significantly attenuated in cells expressing TDAG8, suggesting neuroprotective potential against acidosis-related cell injury. Our results open up new areas of investigation into the relevance of TDAG8 in pH homeostasis and pathological states associated with acid-base dys-regulation in the brain such as ischemia and panic disorder.
登录
查看更多内容
影响因子：
3.5
作者：
Huang, Chia-Wei;Tzeng, Jian-Ning;Sun, Wei-Hsin
通讯作者：
Sun, Wei-Hsin
影响因子：
4.8
作者：
Semtner, Marcus;Schaefer, Michael;Plant, Tim D.
通讯作者：
Plant, Tim D.
影响因子：
4.8
作者：
Wang, JQ;Kon, J;Okajima, F
通讯作者：
Okajima, F
影响因子：
4.8
作者：
Malone, MH;Wang, ZQ;Distelhorst, CW
通讯作者：
Distelhorst, CW
影响因子：
64.8
作者：
Waldmann, R;Champigny, G;Lazdunski, M
通讯作者：
Lazdunski, M