Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants.
Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants.
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CCC1 的序列、作图和破坏，CCC1 是一种交叉互补 csg1 突变体 Ca(2 ) 敏感表型的基因。
DOI：
10.1002/yea.320100411
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Dunn,T
中科院分区：
文献类型：
--
作者：
Fu,D;Beeler,T;Dunn,T
我们已经从酿酒酵母中分离、测序、定位和破坏了一个新的基因CCC1。该基因显示了由secsg1突变产生的钙敏感表型的非等位基因互补。该基因每个细胞有两个拷贝，能够逆转secsg1缺陷，这表明它可能在调节钙稳态方面发挥作用。CCC1的序列分析表明，它编码一个322个氨基酸的膜相关蛋白。CCC1基因位于第12号染色体的右臂上。该序列已保存在GenBank数据库中，登录号为L24112。
We have isolated, sequenced, mapped and disrupted a novel gene,CCC1, fromSaccharomyces cerevisiae. This gene displays non‐allelic complementation of the Ca2+‐sensitive phenotype conferred by thecsg1mutation. The ability of this gene, in two copies per cell, to reverse thecsg1defect suggests it may have a role in regulating Ca2+homeostasis. The sequence ofCCC1indicates that it encodes a 322 amino acid, membrane‐associated protein. TheCCC1gene is located on the right arm of chromosome XII. The sequence has been deposited in the GenBank data library under Accession Number L24112.