Androgen-induced suppression of autoimmune disease in lacrimal glands of mouse models of Sjögren's syndrome.
Androgen-induced suppression of autoimmune disease in lacrimal glands of mouse models of Sjögren's syndrome.
复制标题
雄激素诱导的干燥综合征小鼠模型泪腺自身免疫性疾病的抑制。
DOI：
10.1007/978-1-4615-2417-5_115
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发表时间：
1994
影响因子：
--
通讯作者：
Sato,EH
中科院分区：
文献类型：
--
作者：
Sullivan,DA;Ariga,H;Vendramini,AC;Rocha,FJ;Ono,M;Sato,EH
大约2,000年前，希腊医生和作家克劳迪亚斯·盖伦提出，一个人的精神状态可能会显著影响一个人对疾病的易感性。1这一假设是迅速发展的神经内分泌免疫学领域的一个历史性里程碑，神经内分泌免疫学是通过认识到神经、内分泌和免疫系统通过双向沟通渠道相互控制而建立的，2 - 7目前，已知超过50种神经递质、激素和促分泌素对细胞、体液和粘膜免疫产生深远影响。2 - 7然而，这些相互作用的确切性质极其依赖于特定信号、靶细胞和局部微环境。8因此，取决于组织，神经内分泌作用可能导致刺激，对免疫表达的抑制或无影响。8作为额外的考虑，抗原暴露于免疫系统可能导致产生许多淋巴细胞细胞因子（如淋巴因子，神经肽，激素），直接调节神经和内分泌功能。2 - 7因此，在神经，内分泌和免疫系统的作用，以促进体内平衡和健康。
Almost 2,000 years ago, Claudius Galen, the Greek physician and writer, proposed that the mental status of an individual may significantly influence one’s susceptibility to disease.1This postulate serves as an historic landmark in the rapidly growing field of neuroendocrinimmunology, which was established through the recognition that the nervous, endocrine and immune systems control each other through bidirectional channels of communication, that employ both similar signals and receptors.2–7At present, over 50 neurotransmitters, hormones and secretagogues are known that exert a profound impact on cellular, humoral and mucosal immunity.2–7However, the exact nature of these interactions is extremely dependent upon the specific signal, target cell, and local microenvironment.8Thus, depending upon the tissue, neuroendocrine action may result in stimulation, inhibition, or no effect, on immune expression.8As an additional consideration, antigenic exposure to the immune system may lead to the generation of numerous lymphocytic cytokines (e.g. lymphokines, neuropeptides, hormones), that directly regulate neural and endocrine function.2–7In consequence, an extensive, triangular interrelationship exists among the neural, endocrine and immune systems that acts to promote homeostasis and health.