Effect of compliance with nicotine gum dosing on weight gained during a quit attempt.
Effect of compliance with nicotine gum dosing on weight gained during a quit attempt.
复制标题
尼古丁口香糖剂量依从性对戒烟尝试期间体重增加的影响。
DOI：
10.1111/j.1360-0443.2010.03244.x
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Garvey,ArthurJ
中科院分区：
文献类型：
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作者：
Ferguson,StuartG;Shiffman,Saul;Rohay,JeffreyM;Gitchell,JosephG;Garvey,ArthurJ
使用尼古丁口香糖可以减少戒烟时增加的体重。在这里，我们研究体重增加和使用足够数量的口香糖之间的关系。为了减轻与相关性分析相关的混杂因素，我们对比了活性口香糖和安慰剂的效果，并前瞻性地分析了结果。设计和设置尼古丁口香糖随机双盲安慰剂对照试验。受试者被要求在治疗的前2个月每天使用9 - 15片口香糖。研究人员将103名受试者随机分为两组，一组是活性口香糖组（2 mg或4 mg），另一组是安慰剂组。我们研究了治疗（活性口香糖组与安慰剂组）和每天使用口香糖[≥9片/天（依从性使用）与<9片/天]之间的相互作用对体重增加的影响。 然而，观察到一个显著的依从性-治疗相互作用（P= 0.005）：在治疗的前14天内使用≥9片/天的活跃口香糖使用者在随访时体重增加较少（0.6 kg对使用<9片/天的1.6 kg，P= 0.017），但随机分配到安慰剂组的参与者没有从依从性使用中获益。 一个类似的依从性治疗的相互作用（P= 0.046）也观察到的依从性的影响进行检查时，积极治疗（2毫克与4毫克）。 在服用安慰剂口香糖的吸烟者中未观察到这种关系。
AimUsing nicotine gum can reduce the amount of weight gained when quitting. Here we examine the relationship between weight gain and use of adequate amounts of gum. To mitigate the confounders associated with correlational analyses, we contrast the effects of active gum and placebo, and analyze outcomes prospectively.Design and settingRandomized double‐blind placebo‐controlled trial of nicotine gum. Participants were instructed to use nine to 15 pieces of gum/day for the first 2 months of treatment.ParticipantsParticipants (n= 103) were randomized to either active (2 mg or 4 mg) or placebo gum.MeasurementsWe examined the effect on weight gain of the interaction between treatment (active versus placebo) and daily gum use [≥9 pieces/day (compliant use) versus < 9 pieces/day].FindingsAfter 30 days of abstinence, smokers treated with active gum had not gained significantly less weight than those on placebo (1.1 kg versus 1.6 kg,P= 0.175). However, a significant compliance–treatment interaction was observed (P= 0.005): active gum users who used ≥9 pieces/day during the first 14 days of treatment had gained less weight at follow‐up (0.6 kg versus 1.6 kg for those who used <9 pieces/day,P= 0.017), but participants randomized to the placebo group saw no such benefit from compliant use. A similar compliance–treatment interaction (P= 0.046) was also observed when the effect of compliance was examined within active treatment (2 mg versus 4 mg).ConclusionsWhen smokers are quitting, those who use more pieces of nicotine gum experience less weight gain in the first 30 days. This relationship is not seen for smokers on placebo gum.