BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: A prospective study
BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: A prospective study
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DOI：
10.1016/j.euroneuro.2012.09.003
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发表时间：
2013-08-01
影响因子：
5.6
通讯作者：
Deuschle, Michael
中科院分区：
文献类型：
--
作者：
Buchmann, Arlette F.;Hellweg, Rainer;Deuschle, Michael
最近的研究强调了神经营养因子，如脑源性神经营养因子（BDNF），在调节参与应激相关疾病的病理生理学的神经回路的可塑性中的重要作用。本研究的目的是探讨BDNF瓦尔（66）Met和5-羟色胺转运蛋白启动子（5-HTTLPR）多态性在调节早期生活逆境对BDNF血浆浓度和抑郁症状的影响中的相互作用。参与者来自一项流行病学队列研究，该研究遵循从出生到年轻成年的早期风险因素的长期结果。在259名个体（119名男性，140名女性）中，对BDNF瓦尔（66）Met和5-HTTLPR多态性进行基因分型，在19岁时评估血浆BDNF。此外，参与者还完成了贝克抑郁量表（BDI）。根据3个月大时评估的家庭逆境指数确定早期逆境。结果表明，BDNF瓦尔和5-HTTLPR L等位基因纯合的个体在暴露于高逆境后显示出BDNF水平显著降低。相反，BDNF水平似乎不受BDNF Met或5-HTTLPR S等位基因携带者的早期心理社会逆境的影响。虽然前一组似乎最容易出现抑郁症状，但早期逆境的影响在后一组中不那么明显。这是第一个初步证据表明，早期生活中的不良经历可能对人类血浆BDNF水平产生持久的后遗症，强调这种效应的易感性受BDNF瓦尔（66）Met和5-HTTLPR基因型的调节。(C)2013年由Elsevier B. V.出版
Recent studies have emphasized an important role for neurotrophins, such as brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural circuits involved in the pathophysiology of stress-related diseases. The aim of the present study was to examine the interplay of the BDNF Val(66)Met and the serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact of early-life adversity on BDNF plasma concentration and depressive symptoms. Participants were taken from an epidemiological cohort study following the long-term outcome of early risk factors from birth into young adulthood. In 259 individuals (119 males, 140 females), genotyped for the BDNF Val(66)Met and the 5-HTTLPR polymorphisms, plasma BDNF was assessed at the age of 19 years. In addition, participants completed the Beck Depression Inventory (BDI). Early adversity was determined according to a family adversity index assessed at 3 months of age. Results indicated that individuals homozygous for both the BDNF Val and the 5-HTTLPR L allele showed significantly reduced BDNF levels following exposure to high adversity. In contrast, BDNF levels appeared to be unaffected by early psychosocial adversity in carriers of the BDNF Met or the 5-HTTLPR S allele. While the former group appeared to be most susceptible to depressive symptoms, the impact of early adversity was less pronounced in the latter group. This is the first preliminary evidence indicating that early-life adverse experiences may have lasting sequelae for plasma BDNF levels in humans, highlighting that the susceptibility to this effect is moderated by BDNF Val(66)Met and 5-HTTLPR genotype. (C) 2013 Published by Elsevier B.V.