Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
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DOI：
10.1161/jaha.115.002014
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发表时间：
2015-06-26
影响因子：
5.4
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Lin X;Zhang X;Guo J;Roberts CK;McKenzie S;Wu WC;Liu S;Song Y
指南建议锻炼有利于心血管健康，尽管通过中间生物标志物将锻炼与心血管健康联系起来的试验证据仍然不一致。我们对随机对照试验进行了荟萃分析，以量化运动对无心血管疾病的成年人的心肺健康以及各种传统和新型心脏代谢生物标志物的影响。两名研究人员根据 Medline、Embase 和 Cochrane Central（1965 年 1 月至 2014 年 3 月）的文献检索选择了 160 项随机对照试验（7487 名受试者）。使用标准化协议提取数据。进行了随机效应荟萃分析和系统评价，以评估运动干预对心肺健康和循环生物标志物的影响。运动显着提高了绝对和相对心肺健康。运动组的血脂状况得到改善，甘油三酯水平较低，高密度脂蛋白胆固醇和载脂蛋白 A1 水平较高。运动组的空腹胰岛素、稳态模型评估——胰岛素抵抗和糖化血红蛋白 A1c 水平较低。与对照组相比，运动组的白细胞介素 18 水平较高，而瘦素、纤维蛋白原和血管紧张素 II 水平较低。此外，我们发现运动效果会因年龄、性别和健康状况而变化，例如年龄 <50 岁的人、男性以及患有 2 型糖尿病、高血压、血脂异常或代谢综合征的人似乎受益更多。这项荟萃分析表明，运动显着改善心肺健康和一些心脏代谢生物标志物。运动的效果会因年龄、性别和健康状况而改变。这项研究的结果对未来有针对性的生活方式干预措施的设计具有重要意义。
Guidelines recommend exercise for cardiovascular health, although evidence from trials linking exercise to cardiovascular health through intermediate biomarkers remains inconsistent. We performed a meta-analysis of randomized controlled trials to quantify the impact of exercise on cardiorespiratory fitness and a variety of conventional and novel cardiometabolic biomarkers in adults without cardiovascular disease. Two researchers selected 160 randomized controlled trials (7487 participants) based on literature searches of Medline, Embase, and Cochrane Central (January 1965 to March 2014). Data were extracted using a standardized protocol. A random-effects meta-analysis and systematic review was conducted to evaluate the effects of exercise interventions on cardiorespiratory fitness and circulating biomarkers. Exercise significantly raised absolute and relative cardiorespiratory fitness. Lipid profiles were improved in exercise groups, with lower levels of triglycerides and higher levels of high-density lipoprotein cholesterol and apolipoprotein A1. Lower levels of fasting insulin, homeostatic model assessment–insulin resistance, and glycosylated hemoglobin A1c were found in exercise groups. Compared with controls, exercise groups had higher levels of interleukin-18 and lower levels of leptin, fibrinogen, and angiotensin II. In addition, we found that the exercise effects were modified by age, sex, and health status such that people aged <50 years, men, and people with type 2 diabetes, hypertension, dyslipidemia, or metabolic syndrome appeared to benefit more. This meta-analysis showed that exercise significantly improved cardiorespiratory fitness and some cardiometabolic biomarkers. The effects of exercise were modified by age, sex, and health status. Findings from this study have significant implications for future design of targeted lifestyle interventions.