Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats
Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats
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DOI：
10.1111/j.1365-3024.2010.01207.x
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发表时间：
2010-06-01
影响因子：
2.2
通讯作者：
Sofronic-Milosavljevic, L.
中科院分区：
文献类型：
--
作者：
Gruden-Movsesijan, A.;Ilic, N.;Sofronic-Milosavljevic, L.
旋毛虫是一种蠕虫，在受感染的宿主中引起Th 2和抗炎型反应。我们以前的研究表明，使用黑暗Agglutination（DA）大鼠T。实验性自身免疫性脑脊髓炎（EAE）严重程度降低。本研究的目的是分析T.螺旋体感染该疾病的临床和组织学表现减少，伴有引流淋巴结细胞中IL-4和IL-10产生增加以及IFN-γ和IL-17产生减少。这表明T.螺旋体感染成功地维持了Th 2细胞因子偏向，而不管EAE诱导。高IL-10表示寄生虫诱导的抗炎和/或调节细胞应答。从T.将感染旋毛虫的大鼠接种到EAE免疫的大鼠中引起EAE的改善，并且在某些情况下保护免于疾病发展。与未感染大鼠相比，该细胞群含有更高比例的CD 4 + CD 25 + Foxp 3+调节细胞，并产生高水平的IL-10。
P>Trichinella spiralis is a helminth that provokes Th2 and anti-inflammatory type responses in an infected host. Our previous studies using Dark Agouti (DA) rats indicated that T. spiralis infection reduced experimental autoimmune encephalomyelitis (EAE) severity in rats. The aim of this study was to analyse the mechanisms underlying EAE suppression driven by T. spiralis infection. Reduced clinical and histological manifestations of the disease were accompanied by increased IL-4 and IL-10 production and decreased IFN-gamma and IL-17 production in draining lymph node cells. This indicates that T. spiralis infection successfully maintains a Th2 cytokine bias regardless of EAE induction. High IL-10 signifies parasite-induced anti-inflammatory and/or regulatory cell responses. Transfer of splenic T cell-enriched population of cells from T. spiralis-infected rats into EAE immunized rats caused amelioration of EAE and in some cases protection from disease development. This population of cells contained higher proportion of CD4+ CD25+ Foxp3+ regulatory cells and produced high level of IL-10 when compared with uninfected rats.