A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue
A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue
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DOI：
10.1016/j.biomaterials.2007.07.030
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发表时间：
2007-12-01
期刊：
影响因子：
14
通讯作者：
Ambrosio, Luigi
中科院分区：
文献类型：
--
作者：
Causa, Filippo;Netti, Paolo A.;Ambrosio, Luigi
在设计用于组织再生的支架时，主要目标是在时间上协调和空间上组织的结构中概括细胞外基质（ECM）功能。一个关键问题是在支架内编码所需的生物信号，以便控制细胞反应的各个方面——粘附和迁移、增殖和表型选择。在实现这一目标的纳米技术中，自下而上的设计方法和固体自由形状制造（SFF）以及自组装工艺将发挥关键作用。对于支架材料，必须在结构特征（尤其是孔隙率）与化学、物理和生物特性之间取得正确的平衡。本文回顾了生物材料设计的主要成就和未来的挑战。 (C) 2007 Elsevier Ltd. 保留所有权利。
In designing scaffolds for tissue regeneration, the principal objective is to recapitulate extracellular matrix (ECM) function in a temporally coordinated and spatially organised structure. A key issue is to encode required biological signals within the scaffold so that all aspects of cell response-adhesion and migration, proliferation and phenotype choice-can be controlled. In achieving this objective nanotechnology, bottom-up design approach and solid free-form fabrication (SFF) will play key roles, along with self-assembly processes. For scaffold materials, there must be the correct balance between architectural features notably, porosity and chemical, physical and biological properties. This paper reviews the main achievements in biomaterials design and the future challenges. (C) 2007 Elsevier Ltd. All rights reserved.