The Vulnerability to Suicidal Behavior is Associated with Reduced Connectivity Strength.
The Vulnerability to Suicidal Behavior is Associated with Reduced Connectivity Strength.
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DOI：
10.3389/fnhum.2015.00632
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发表时间：
2015
影响因子：
2.9
通讯作者：
van Heeringen C
中科院分区：
文献类型：
--
作者：
Bijttebier S;Caeyenberghs K;van den Ameele H;Achten E;Rujescu D;Titeca K;van Heeringen C
自杀行为构成了一个重大的公共卫生问题。基于应激-素质模型，一种素质的生物学相关性可能有助于预测应激暴露后的风险。皮层和皮层下区域的结构变化及其联系越来越多地与素质联系在一起。目前的研究使用全脑方法，通过检查自杀未遂者（SA）区域之间的结构连接，确定了与素质相关的结构网络变化。此外，还研究了连通性测量、临床和遗传特征之间的关系。我们假设SA表现出较低的连接强度，与一般临床特征的严重程度增加和5 -羟色胺多态性中短等位基因的表达升高有关。13例优乐期SA患者与15例优乐期未尝试者和17例健康对照（HC）进行比较。评估临床特征和3种血清素相关的遗传多态性。同时进行弥散MRI和解剖扫描。使用Explore DTI进行预处理。全脑束造影的弥散加权图像后，采用NBS进行流线加权网络分析。网络分析显示左侧嗅觉皮层与左侧前扣带回连接的SA连接强度降低。此外，SA增加了自杀意念、绝望和自我报告的抑郁，但在遗传多态性上没有表现出任何差异。最后，右脑胼胝体裂与左枕中回连接强度较低与特质焦虑严重程度（rs = - 0.78, p < 0.01）和绝望感（rs = - 0.76, p < 0.01）增加相关。SA显示与临床特征相关的白质网络连接强度的差异。总之，这些变量可能在预测自杀行为方面发挥重要作用。
Suicidal behavior constitutes a major public health problem. Based on the stress–diathesis model, biological correlates of a diathesis might help to predict risk after stressor-exposure. Structural changes in cortical and subcortical areas and their connections have increasingly been linked with the diathesis. The current study identified structural network changes associated with a diathesis using a whole-brain approach by examining the structural connectivity between regions in euthymic suicide attempters (SA). In addition, the association between connectivity measures, clinical and genetic characteristics was investigated. We hypothesized that SA showed lower connectivity strength, associated with an increased severity of general clinical characteristics and an elevated expression of short alleles in serotonin polymorphisms. Thirteen euthymic SA were compared with fifteen euthymic non-attempters and seventeen healthy controls (HC). Clinical characteristics and three serotonin-related genetic polymorphisms were assessed. Diffusion MRI together with anatomical scans were administered. Preprocessing was performed using Explore DTI. Whole brain tractography of the diffusion-weighted images was followed by a number of streamlines-weighted network analysis using NBS. The network analysis revealed decreased connectivity strength in SA in the connections between the left olfactory cortex and left anterior cingulate gyrus. Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms. Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = −0.78, p < 0.01) and hopelessness (rs = −0.76, p < 0.01). SA showed differences in white matter network connectivity strength associated with clinical characteristics. Together, these variables could play an important role in predicting suicidal behavior.