A mixed incoherent feed-forward loop contributes to the regulation of bacterial photosynthesis genes.
A mixed incoherent feed-forward loop contributes to the regulation of bacterial photosynthesis genes.
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DOI：
10.4161/rna.23769
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发表时间：
2013-03
期刊：
影响因子：
4.1
通讯作者：
Klug G
中科院分区：
文献类型：
--
作者：
Mank NN;Berghoff BA;Klug G
活细胞使用各种调控网络基序来准确表达基因，以响应环境的变化或在分化过程中。在球形红杆菌中，一个复杂的调控网络控制光合作用基因的表达，一方面保证最佳的能量供应，另一方面避免光氧化胁迫。最近，我们发现了一个由转录因子PrrA、SRNA PcrZ和光合作用靶基因组成的混合非相干前馈环作为这个调控网络的一部分。这一观点提供了与其他描述的前馈环路的比较，并更详细地讨论了PcrZ的生理相关性。
Living cells use a variety of regulatory network motifs for accurate gene expression in response to changes in their environment or during differentiation processes. In Rhodobacter sphaeroides, a complex regulatory network controls expression of photosynthesis genes to guarantee optimal energy supply on one hand and to avoid photooxidative stress on the other hand. Recently, we identified a mixed incoherent feed-forward loop comprising the transcription factor PrrA, the sRNA PcrZ and photosynthesis target genes as part of this regulatory network. This point-of-view provides a comparison to other described feed-forward loops and discusses the physiological relevance of PcrZ in more detail.