Neurovascular function in the rat during pregnancy.
Neurovascular function in the rat during pregnancy.
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DOI：
10.1152/ajpheart.1986.251.5.h1000
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发表时间：
1986-11
期刊：
影响因子：
--
通讯作者：
J. Hart;W. Freas;S. Muldoon
中科院分区：
文献类型：
--
作者：
J. Hart;W. Freas;S. Muldoon
在妊娠（PG）和非妊娠（NPG）大鼠中检查血管神经效应器接头的活性，以确定变化是否可以解释所报告的母体循环交感神经控制的改变。从NPG和19-21天PG大鼠中取出尾动脉和肠系膜动脉，并准备用于等长张力记录。获得频率响应测量值，然后进行去甲肾上腺素（NE）和酪胺浓度响应测量。尾动脉开发更多的张力在响应NE，酪胺，和电刺激比肠系膜动脉，但是，有没有从NPG和PG大鼠血管之间的差异。比较了NPG和PG尾动脉的NE含量、[3 H]NE蓄积以及血浆对[3 H]NE蓄积的影响，发现两者相似。因此，在大鼠妊娠期间，NE释放、受体敏感性和NE累积的血管神经效应器功能未被修改。母体循环的交感神经控制的变化可能依赖于神经效应器接头以外的部位的改变。
Activity of the vascular neuroeffector junction was examined in pregnant (PG) and nonpregnant (NPG) rats to determine whether changes could account for the reported alterations in sympathetic control of the maternal circulation. Caudal and mesenteric arteries were removed from NPG and 19-21 day PG rats and prepared for isometric tension recording. Frequency-response measurements were obtained, followed by norepinephrine (NE) and tyramine concentration-response measurements. The caudal artery developed more tension in response to NE, tyramine, and electrical stimulation than did the mesenteric artery; however, there were no differences between vessels from NPG and PG rats. NE content, [3H]NE accumulation, and effects of plasma on [3H]NE accumulation of NPG and PG caudal arteries were also compared and found to be similar. Therefore, vascular neuroeffector functions of NE release, receptor sensitivity, and NE accumulation are not modified in the rat during pregnancy. Changes in sympathetic control of the maternal circulation are likely to be dependent on alterations at sites other than the neuroeffector junction.