GASTRIC CANCER IN COLOMBIA .3. NATURAL-HISTORY OF PRECURSOR LESIONS
GASTRIC CANCER IN COLOMBIA .3. NATURAL-HISTORY OF PRECURSOR LESIONS
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DOI：
10.1093/jnci/57.5.1027
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发表时间：
1976-01-01
影响因子：
10.3
通讯作者：
HAENSZEL, W
中科院分区：
文献类型：
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作者：
CORREA, P;CUELLO, C;HAENSZEL, W
通过对哥伦比亚人群的胃镜调查，研究了胃粘膜癌前病变的过程，并计算了具有极高胃癌风险(Narino)、极低风险(卡塔赫纳)和中等风险(CALI)的人群样本的浅表性胃炎、慢性萎缩性胃炎和肠化生的患病率。连续年龄组中黏膜正常的个体的患病率被用来估计耗竭曲线，这被作为每个社区癌前过程的动态指标。研究发现，不同地理位置的人患胃癌的风险存在差异。在纳里诺的高危地区，.apprx。75%的人在45岁前患上了某种类型的胃炎；在卡塔赫纳和卡利的低风险和中等风险人群中，此类病变的比例在45岁或以后不超过50%。早期生活中的环境因素对确定每个人群中病变的患病率似乎很重要。
The premalignant process in the gastric mucosa was studied by gastroscopic surveys of Colombian populations, and the prevalence of superficial gastritis, chronic atrophic gastritis and intestinal metaplasia was calculated for population samples having a very high gastric cancer risk (Narino), very low risk (Cartagena) and intermediate risk (Cali). The prevalence of individuals with normal mucosa in successive age groups was used to estimate depletion curves, which were taken as indicators of the dynamics of the premalignant process in each community. Differences corresponding to the geographic variation in stomach cancer risk were found. In the high-risk areas of Narino, .apprx. 75% of the population developed some type of gastritis by 45 yr of age; in the low- and intermediate-risk populations of Cartagena and Cali, the proportion of such lesions did not exceed 50% at age 45 or thereafter. The effect of environmental factors in early life seemed important in determining the prevalence of lesions in each population.