Treatment of hepatocellular carcinoma with sub-selective transcatheter arterial oily chemoinfusion.
Treatment of hepatocellular carcinoma with sub-selective transcatheter arterial oily chemoinfusion.
复制标题
亚选择性经导管动脉油性化疗输注治疗肝细胞癌。
DOI：
--
复制
发表时间：
2002
影响因子：
1.7
通讯作者：
M. Razavi
中科院分区：
文献类型：
--
作者：
Pamina S. Kim;W. Prapong;D. Sze;S. So;M. Razavi
原发性肝癌的经动脉治疗越来越被接受。然而，这种癌症的经动脉治疗技术是相当不同的。为了确定我们的方法的价值，我们分析了我们在4.9年的时间内对原发性肝癌进行经动脉油性化疗灌注（TOCI）的经验。自1997年以来，我们机构已进行了300多例此类手术。我们报告了前253例手术的结果，这些手术采用亚段技术，使用多柔比星、顺铂、硫碘油的混合物，选择性明胶海绵栓塞。采用Kaplan-Meier法计算1年、2年和3年的精算生存率，采用考克斯回归进行多因素分析。诊断后的中位总生存期为28.6 +/- 4.5个月。通过单因素分析，TNM临床分期I或II、Karnofsky评分> 80%、无肝外疾病、无血管侵犯、单灶性疾病、治疗前甲胎蛋白水平<500 ng/ml、病灶血管丰富、病灶大小<5 cm均为患者1、2和3年生存率的强预测因素（75%，60%，50%）。根据我们的经验，选择性栓塞的TOCI具有与传统化疗栓塞相似的生存获益，但并发症较少。
Transarterial therapy for primary liver cancer is gaining more acceptance. The technique of transarterial treatment of such cancers is, however, quite varied. To determine the value of our approach, we analyzed our experience with transarterial oily chemoinfusion (TOCI) of primary liver cancer over a 4.9-year period. Since 1997, over 300 such procedures have been performed at our institution. We report the results of the first 253 procedures, which were performed using a subsegmental technique with a mixture of doxorubicin, cisplatin, ethiodol, with selective Gelfoam embolization. Actuarial survival rates at 1, 2, and 3 years were calculated with Kaplan-Meier and multivariate analysis was performed by Cox regression. The median overall survival was 28.6 +/- 4.5 months following diagnosis. By univariate analysis, TNM clinical stage I or II, Karnofsky score above 80%, absence of extrahepatic disease, absence of vascular invasion, unifocal disease, pretreatment alpha-fetoprotein levels less than 500 ng/ml, hypervascularity of lesions, and lesion size less than 5 cm were all strong predictors of favorable patient survival at 1, 2, and 3 years (75%, 60%, and 50% respectively). Based on our experience, TOCI with selective embolization has similar survival benefit as the traditional chemoembolization but is associated with fewer complications.
原发性肝细胞癌——病因、发病机制和预防。
影响因子：
3.3
作者：
London,WT
通讯作者：
London,WT