Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
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鳞状癌细胞中岩藻糖基转移酶 IV 的差异表达受启动子甲基化调节
DOI：
10.2478/s11658-012-0003-x
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发表时间：
2012-06
影响因子：
8.3
通讯作者：
Wang XQ
中科院分区：
文献类型：
--
作者：
Li H;Tong S;Liu J;Han L;Yang X;Hou H;Yan Q;Wang XQ
岩藻糖基转移酶IV（FUT4）表达增强与许多癌症中肿瘤恶性程度增加相关。然而，对FUT4表达的调控知之甚少，FUT4表达是否受FUT4启动子甲基化状态的影响尚不清楚。在这项研究中，我们证明了FUT4表达与FUT4启动子中CpG岛的甲基化程度呈负相关，表明FUT4启动子的甲基化状态调节FUT4的表达。结果表明，操纵FUT4启动子的甲基化状态来调节FUT4表达可能是恶性肿瘤治疗的新方法。
Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.