Dietary freshwater clam (Corbicula fluminea) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats
Dietary freshwater clam (Corbicula fluminea) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats
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膳食淡水蛤（Corbicula Fluminea）提取物抑制大鼠肝脏脂质积累，并增加膳食氯酮诱导的大鼠血清胆固醇和转氨酶活性
DOI：
10.1080/09168451.2015.1012147
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mochizuki S
中科院分区：
文献类型：
--
作者：
Chijimatsu T;Umeki M;Kataoka Y;Kobayashi S;Kataoka Y;Yamada K;Oda H;Mochizuki S
我们研究了淡水蛤提取物（FCE）对暴露于藜芦酮的大鼠脂肪肝、高胆固醇血症和肝损伤的改善作用。此外，我们研究了主要FCE组分（脂肪和蛋白质组分）的影响，以确定FCE中的活性组分。Chloretone增加血清转氨酶活性，导致肝脏脂质蓄积。血清转氨酶活性和肝脏脂质含量较低的大鼠喂养总FCE或脂肪/蛋白质组分的FCE。藜芦酮可上调脂肪酸合成酶和脂肪酸去饱和酶基因的表达。总FCE和脂肪/蛋白质馏分FCE抑制参与脂肪酸合成的基因表达的增加。血清胆固醇水平增加两倍后，炔雌醇暴露。总FCE或FCE的脂肪/蛋白质组分在藜芦酮诱导的高胆固醇血症大鼠中显示出降低胆固醇的作用。这些表明，FCE含有至少两种活性成分，对脂肪肝，高胆固醇血症，肝损伤大鼠暴露于藜芦酮。
We investigated the ameliorative effect of freshwater clam extract (FCE) on fatty liver, hypercholesterolemia, and liver injury in rats exposed to chloretone. Furthermore, we examined the effects of major FCE components (fat and protein fractions) to determine the active components in FCE. Chloretone increased serum aminotransferase activities and led to hepatic lipid accumulation. Serum aminotransferase activities and hepatic lipid content were lower in rats fed total FCE or fat/protein fractions of FCE. Expression of fatty acid synthase and fatty acid desaturase genes was upregulated by chloretone. Total FCE and fat/protein fractions of FCE suppressed the increase in gene expression involved in fatty acid synthesis. Serum cholesterol levels increased twofold upon chloretone exposure. Total FCE or fat/protein fractions of FCE showed hypocholesterolemic effects in rats with hypercholesterolemia induced by chloretone. These suggest that FCE contains at least two active components against fatty liver, hypercholesterolemia, and liver injury in rats exposed to chloretone.