INSULIN RECEPTORS ARE WIDELY DISTRIBUTED IN CENTRAL NERVOUS-SYSTEM OF RAT
INSULIN RECEPTORS ARE WIDELY DISTRIBUTED IN CENTRAL NERVOUS-SYSTEM OF RAT
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DOI：
10.1038/272827a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
ROTH, J
中科院分区：
文献类型：
--
作者：
HAVRANKOVA, J;ROTH, J
虽然胰岛素可以通过产生低血糖来影响中枢神经系统(CNS)的功能，但有大量证据表明，胰岛素也可以直接作用于中枢神经系统的细胞来改变它们的功能1-4。在对胰岛素受体系统发展的研究中，Posner5报道了125I-胰岛素与大鼠、猴子和鸽子全脑的膜制剂的特异性结合。在猴子的下丘脑中检测到了胰岛素的特定受体，但在大脑皮层或丘脑中没有检测到6；中枢神经系统的其他区域也没有被研究。我们在这里报告了在大鼠中枢神经系统的离散区域中存在大量浓度的胰岛素受体。我们在研究的每个地区都检测到了胰岛素的特异性结合，尽管不同地区之间的差异高达5到10倍。大脑皮层的胰岛素受体具有最广泛的特征，根据所有标准，它与经典靶组织(肝脏、肌肉和脂肪)以及人类、轮虫7-10和其他哺乳动物和非哺乳类脊椎动物的其他细胞上的胰岛素受体无法区分。
WHILE insulin can affect the function of the central nervous system (CNS) by producing hypoglycaemia, there is substantial evidence suggesting that insulin can also act directly on cells of the CNS to modify their function1–4. In a study of the phylogeny of the insulin receptor, Posner5reported specific binding of125I-insulin to membrane preparations from whole brain of rat, monkey and pigeon. Specific receptors for insulin have been detected in the hypothalamus of monkeys but not in the cerebral cortex or thalamus6; other regions of the CNS were not studied. We report here the presence of substantial concentrations of insulin receptors in discrete regions of the CNS of the rat. We detected specific binding of insulin in every area studied, although it differed by as much as five- to 10-fold among regions. The insulin receptor of the cerebral cortex was most extensively characterised, and by all criteria it was indistinguishable from the insulin receptor on classical target tissues (liver, muscle and fat) as well as other cells of humans, rodents7–10, and other mammals and non-mammalian vertebrates.