Sleep disturbances in young subjects with visual dysfunction.
Sleep disturbances in young subjects with visual dysfunction.
复制标题
患有视觉功能障碍的年轻受试者的睡眠障碍。
DOI：
10.1016/j.ophtha.2003.05.014
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
VanGelder,RussellN
中科院分区：
文献类型：
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作者：
Wee,Raymond;VanGelder,RussellN
为了确定眼科疾病的类型是否预示着患有视觉功能障碍的年轻受试者的睡眠和觉醒障碍。设计前瞻性队列研究。研究对象是来自密苏里州盲人学校的25名受试者(年龄12-20岁)。12名视力正常的对照组来自一所寄宿学校。方法用腕部活动记录仪监测14天的辅助活动。睡眠和觉醒的测量是通过自动分析从活动记录中得出的。结果视神经疾病受试者白天打盹的时间显著多于其他视力受损儿童或视力正常的对照组：28.1±4.0分钟/天(平均±标准差)比11.9±2.4分钟/天(P<；0.0001)。这些受试者也表现出比其他组更多的可变觉醒时间。Logistic回归分析显示，视神经疾病患者每天午睡时间超过20分钟的可能性是同等失明的非视神经疾病患者的9.1倍(95%可信区间[CI]=1.4~58.7，P=0.02)。患有视神经疾病的盲人平均每天午睡时间超过20min的概率是视力正常儿童的21.3倍(95%CI=1.2~378，P=0.04)。结论视神经疾病是青少年视障患者白天午睡增加的预测因素，提示眼科疾病的性质和是否存在影响伴随的睡眠计时障碍的概率。
PURPOSETo determine whether the type of ophthalmic disease is predictive of sleep and wakefulness disturbances in young subjects with visual dysfunction.DESIGNProspective cohort study.PARTICIPANTS AND CONTROLSTwenty-five subjects (ages 12–20) were recruited from the Missouri School for the Blind. Twelve controls with normal sight were recruited from a residential school.METHODSDaily activity was monitored for 14 days using wrist actigraphy. Sleep and wakefulness measures were derived from actigraphy records by automated analysis. Visually impaired subjects were prospectively stratified by presence or absence of optic nerve disease.MAIN OUTCOME MEASURESDaytime napping and regularity of awakening time (wake-up time instability).RESULTSSubjects with optic nerve disease napped in the daytime significantly more than other visually impaired children or normal sighted controls: 28.1±4.0 minutes per day (mean ± standard error) versus 11.9±2.4 minutes per day in equally visually impaired subjects with intact optic nerve function versus 6.2±2.2 minutes per day in subjects with normal sight (P<0.0001). These subjects also showed significantly more variable awakening times than the other groups. Logistic regression revealed that subjects with optic nerve disease are 9.1 times more likely to demonstrate daily napping of more than 20 minutes per day than equally blind subjects without optic nerve disease (95% confidence interval [CI] = 1.4–58.7, P = 0.02). Blind subjects with optic nerve disease are 21.3 times more likely than children with normal sight to nap more than 20 minutes on average per day (95% CI = 1.2–378, P = 0.04).CONCLUSIONSOptic nerve disease is predictive of increased daytime napping in young visually impaired subjects, suggesting that the nature and presence of ophthalmic disease affect the probability of concomitant sleep timing disorders.