LIPOSOMAL VACCINES - CLINICAL STATUS AND IMMUNOLOGICAL PRESENTATION FOR HUMORAL AND CELLULAR-IMMUNITY
LIPOSOMAL VACCINES - CLINICAL STATUS AND IMMUNOLOGICAL PRESENTATION FOR HUMORAL AND CELLULAR-IMMUNITY
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DOI：
10.1111/j.1749-6632.1995.tb44447.x
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发表时间：
1995-01-01
期刊：
影响因子：
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通讯作者：
ALVING, CR
中科院分区：
文献类型：
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作者：
ALVING, CR
脂质体已被提议作为针对寄生虫和病毒疾病的疫苗的载体。针对疟疾、艾滋病毒、甲型肝炎和流感病毒的实验性疫苗已在几项人体试验中显示出安全性和高度免疫原性。脂质体抗原的细胞内运输模式的分析揭示，在被巨噬细胞吞噬后，脂质体抗原容易从内体逃逸到巨噬细胞的细胞质中。有人提出，脂质体肽抗原可以进入高尔基体或内质网，从而与MHC II类或I类分子相互作用。脂质体抗原的细胞内胞质运输模式提高了脂质体在人疫苗中用于诱导体液免疫或细胞毒性T淋巴细胞的可能性。
Liposomes have been proposed as vehicles for vaccines against parasitic and viral illnesses. Experimental vaccines against malaria, HIV, hepatitis A, and influenza virus have been shown to be safe and highly immunogenic in several human trials. Analysis of the intracellular trafficking patterns of liposomal antigen reveals that after being phagocytosed by macrophages, liposomal antigen readily escapes from endosomes into the cytoplasm of the macrophages. It is proposed that liposomal peptide antigen can enter either the Golgi apparatus or the endoplasmic reticulum and thereby interact with MHC class II or class I molecules. The intracellular cytoplasmic trafficking patterns of liposomal antigens raise the possibility that liposomes may have utility in human vaccines for induction of either humoral immunity or cytotoxic T lymphocytes.