Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
复制标题
SARS-COV-2的抗体防止在2020年9月和10月10日在养老院爆发期间再感染。
DOI：
10.2807/1560-7917.es.2021.26.5.2100092
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Zambon M
中科院分区：
文献类型：
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作者：
Jeffery-Smith A;Iyanger N;Williams SV;Chow JY;Aiano F;Hoschler K;Lackenby A;Ellis J;Platt S;Miah S;Brown K;Amirthalingam G;Patel M;Ramsay ME;Gopal R;Charlett A;Ladhani SN;Zambon M
伦敦两家养老院经历了第二次COVID-19疫情，209例（13.9%）SARS-CoV-2 RT-PCR阳性病例（16/103名居民，13/106名工作人员）。在那些先前接触过SARS-CoV-2的人中，1/88（1.1%）人（抗体阳性：87; RT-PCR阳性：1）成为PCR阳性，而22/73（30.1%）人确认为血清阴性。4个月后，使用比例比较的风险比，既往感染对再感染的保护率为96.2%（95%置信区间（CI）：72.7-99.5%），使用惩罚logistic回归模型，为96.1%（95% CI：78.8-99.3%）。
Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8–99.3%) using a penalised logistic regression model.