Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.
Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.
复制标题
DOI：
10.1016/j.ccr.2012.02.018
复制
发表时间：
2012-04-17
期刊：
影响因子：
50.3
通讯作者：
Bhatia R
中科院分区：
文献类型：
--
作者：
Zhang B;Ho YW;Huang Q;Maeda T;Lin A;Lee SU;Hair A;Holyoake TL;Huettner C;Bhatia R
我们使用转基因小鼠模型表征了慢性期慢性粒细胞白血病（CML）中的白血病干细胞（LSC）。LSC仅限于具有长期造血干细胞（LTHSC）表型的细胞。CML LTHSC表现出在骨髓（BM）中的归巢和滞留减少，这与CML BM中CXCL 12表达减少有关，这是由白血病细胞产生的G-CSF增加引起的。CML BM中细胞因子表达的改变与正常LTHSC生长的选择性损害和CML LTHSC的生长优势相关。伊马替尼（IM）治疗部分纠正了细胞因子水平和LTHSC生长的异常。这些结果使用人类CML样本进行了验证，并提供了对正常和白血病LTHSC的微环境调节及其对CML中IM的反应的更好理解。
We characterized leukemia stem cells (LSC) in chronic phase chronic myelogenous leukemia (CML) using a transgenic mouse model. LSC were restricted to cells with long-term hematopoietic stem cell (LTHSC) phenotype. CML LTHSC demonstrated reduced homing and retention in the bone marrow (BM), related to decreased CXCL12 expression in CML BM, resulting from increased G-CSF production by leukemia cells. Altered cytokine expression in CML BM was associated with selective impairment of normal LTHSC growth and a growth advantage to CML LTHSC. Imatinib (IM) treatment partially corrected abnormalities in cytokine levels and LTHSC growth. These results were validated using human CML samples and provide improved understanding of microenvironmental regulation of normal and leukemic LTHSC and their response to IM in CML.
登录
查看更多内容
影响因子：
20.3
作者：
BHATIA, R;MCGLAVE, PB;VERFAILLIE, CM
通讯作者：
VERFAILLIE, CM
影响因子：
32.4
作者：
Mansson, Robert;Hultquist, Anne;Jacobsen, Sten Eirik W.
通讯作者：
Jacobsen, Sten Eirik W.
影响因子：
64.5
作者：
Kiel, MJ;Yilmaz, ÖH;Morrison, SJ
通讯作者：
Morrison, SJ
影响因子：
158.5
作者：
Druker, Brian J.;Guilhot, Francois;Larson, Richard A.
通讯作者：
Larson, Richard A.
影响因子：
158.5
作者：
Jamieson, CHM;Ailles, LE;Weissman, IL
通讯作者：
Weissman, IL