ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle
ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle
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DOI：
10.4161/cc.8.12.8800
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发表时间：
2009-06-15
期刊：
影响因子：
4.3
通讯作者：
Drobetsky, Elliot A.
中科院分区：
文献类型：
--
作者：
Auclair, Yannick;Rouget, Raphael;Drobetsky, Elliot A.
核苷酸切除修复（NER）是癌症发展和治疗的主要决定因素，它在消除阻断复制和转录的高基因毒性、螺旋扭曲的DNA加合物中发挥重要作用。多年来，许多采用紫外线作为模型诱变剂的精美研究已经导致对NER途径本身如何协调的详细了解。尽管如此，对于NER上游各种卓越的诱变反应信号级联的精确功能，特别是那些由典型mapk或PIKK家族成员ATR和ATM介导的信号级联，人们所知相对较少。在这里，我们简要概述了NER，主要是在紫外线处理的人类细胞研究的背景下，并描述了我们实验室最近的结果，这些结果已经显著阐明了紫外线诱导的信号转导在这种修复途径中的作用。
Nucleotide excision repair (NER) is a major determinant in cancer development and treatment via its essential role in eliminating highly-genotoxic, helix-distorting DNA adducts that block replication and transcription. Over the years, many elegant studies employing UV as model mutagen have led to a detailed understanding of how the NER pathway itself is coordinated. Nonetheless relatively little is known regarding any precise functions of various preeminent mutagen-responsive signaling cascades lying upstream of NER, notably those mediated by the canonical MAPKs or the PIKK family members ATR and ATM. Here we present a brief overview of NER, mostly in the context of studies on human cells treated with UV, and describe recent results from our laboratory which have significantly elucidated the role of UV-induced signal transduction in this repair pathway.