Impact of temperature elevation on immunologic defenses.
Impact of temperature elevation on immunologic defenses.
复制标题
温度升高对免疫防御的影响。
DOI：
10.1093/clinids/13.3.462
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
RobertsJr,NJ
中科院分区：
文献类型：
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作者：
RobertsJr,NJ
发烧是对感染和对宿主防御的其他挑战的常见反应。温度升高与免疫应答的识别、募集和效应阶段的影响相关。特异性免疫反应通常在生理范围内而不是超生理范围内的温度升高中增强。相反，天然免疫反应可能不变或受到不利影响。温度升高似乎主要影响单核白细胞的识别和致敏或活化阶段。T淋巴细胞应答（和/或T淋巴细胞与单核细胞-巨噬细胞的相互作用）被增强以产生效应细胞。效应细胞的活性一旦产生，通常不会因温度升高而增强，甚至可能被抑制，但其减少会被T辅助细胞功能的增加所抵消。总的来说，数据表明，温度升高的发热反应构成了有效的主机防御的有益组成部分。
Fever is a common response to infection and to other challenges to host defense. Temperature elevation has been associated with effects on the recognition, recruitment, and effector phases of the immune response. Specific immunologic responses are generally enhanced in the setting of temperature elevation within the physiologic range but not the supraphysiologic range. In contrast, natural immune responses may be unchanged or adversely affected. Temperature elevation appears to affect primarily the phase of recognition and sensitization or activation of mononuclear leukocytes. T lymphocyte responses (and/or the interactions of T lymphocytes with monocytes-macrophages) are enhanced for generation of effector cells. The activities of the effector cells, once generated, are usually not enhanced — or may even be depressed — by temperature elevation, but decreases are more than offset by increased T helper function. Overall, the data suggest that temperature elevations of the febrile response constitute a beneficial component of effective host defense.