Effect of temporal lobe structure volume on memory in elderly depressed patients
Effect of temporal lobe structure volume on memory in elderly depressed patients
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DOI：
10.1016/j.neurobiolaging.2009.11.004
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发表时间：
2011-10-01
影响因子：
4.2
通讯作者：
Bottino, Cassio M. C.
中科院分区：
文献类型：
--
作者：
Avila, Renata;Ribeiz, Salma;Bottino, Cassio M. C.
目的：比较患有和不患有抑郁症的老年人的海马和海马旁回的体积，并确定这些区域的体积是否与记忆测试分数相关。方法：评估了 48 名患有抑郁症的老年患者和 31 名对照受试者的临床和人口统计学差异以及区域灰质体积的差异。使用统计参数映射和基于体素的形态测量来处理脑（结构 MRI）扫描。对两组受试者进行认知测试。结果：海马或海马旁回的灰质体积没有组间差异。仅在老年抑郁症组中，左侧海马旁回的体积与视觉言语学习测试的延迟命名部分的分数相关。在抑郁症受试者中，左侧海马体、右侧和左侧海马旁回的体积与言语情景记忆测试和视觉学习测试的即时回忆分数之间也存在显着的直接相关性。在对照组中，仅整体认知表现（用 MMSE 评估）与右侧海马体积之间以及视觉语言学习测试总分与左右海马旁回体积之间存在直接相关性。结论：这些发现强调了抑郁症个体和健康老年受试者的认知表现与内侧颞叶结构体积之间的不同模式关系。延迟视觉语言记忆回忆分数与左侧海马旁体积之间的直接相关性，特别是在老年抑郁症患者中，支持了老年人群抑郁症可能是痴呆症危险因素的观点。 (C) 2009 Elsevier Inc. 保留所有权利。
Objective: To compare the volume of the hippocampus and parahippocampal gyrus in elderly individuals with and without depressive disorders, and to determine whether the volumes of these regions correlate with scores on memory tests.Method: Clinical and demographic differences, as well as differences in regional gray matter volumes, were assessed in 48 elderly patients with depressive disorders and 31 control subjects. Brain (structural MRI) scans were processed using statistical parametric mapping and voxel-based morphometry. Cognitive tests were administered to subjects in both groups.Results: There were no between-group gray matter volume differences in the hippocampus or parahippocampal gyrus. In the elderly depressed group only, the volume of the left parahippocampal gyrus correlated with scores on the delayed naming portion of the visual verbal learning test. There were also significant direct correlations in depressed subjects between the volumes of the left hippocampus, right and left parahippocampal gyrus and immediate recall scores on verbal episodic memory tests and visual learning tests. In the control group, there were direct correlations only between overall cognitive performance (as assessed with the MMSE) and the volume of right hippocampus, and between the total score on the visual verbal learning test and the volume of the right and left parahippocampal gyrus.Conclusions: These findings highlight different patterns of relationship between cognitive performance and volumes of medial temporal structures in depressed individuals and healthy elderly subjects. The direct correlation between delayed visual verbal memory recall scores with left parahippocampal volumes specifically in elderly depressed individuals provides support to the view that depression in elderly populations may be a risk factor for dementia. (C) 2009 Elsevier Inc. All rights reserved.