Saturation kinetics of palmitate uptake in perfused skeletal muscle

Saturation kinetics of palmitate uptake in perfused skeletal muscle
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灌注骨骼肌中棕榈酸酯摄取的饱和动力学

DOI:
10.1016/0014-5793(91)80180-b
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发表时间:
1991
期刊:
影响因子:
3.5
通讯作者:
E. Richter
E. Richter
中科院分区:
生物学3区
文献类型:
--
作者:
L. Turcotte;B. Kiens;E. Richter

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我们研究了一种生理骨骼肌制剂中棕榈酸酯摄取的动力学。当与游离血浆棕榈酸酯浓度进行比较时,棕榈酸的摄取量符合简单的米氏方程,其Vmax和Km值分别为16.3nmol.min−1·g−1和0.06nmol.Lμ−1。这些结果表明,与在分离的细胞系统中一样,骨骼肌对游离脂肪酸的摄取遵循与载体介导的游离脂肪酸膜转运一致的饱和动力学。
We investigated the kinetics of palmitate uptake in a physiological skeletal muscle preparation by using the isolated perfused rat hindquarter. When plotted against the unbound plasma palmitate concentration, palmitate uptake displayed a simple Michaelis-Menten relation with a calculatedVmaxandKmof 16.3 nmol · min−1· g−1and 0.06 μmol·l−1, respectively. These results show that, as in isolated cell systems, uptake of free fatty acids in perfused skeletal muscle follows saturation kinetics consistent with carrier-mediated membrane transport of free fatty acids.
DOI: 10.1073/pnas.82.1.4
发表时间: 1985
影响因子: 11.1
作者:
W. Stremmel;G. Strohmeyer;F. Borchard;S. Kochwa;P. Berk
通讯作者: W. Stremmel;G. Strohmeyer;F. Borchard;S. Kochwa;P. Berk