The Determinants of Directionality in Transcriptional Initiation.
The Determinants of Directionality in Transcriptional Initiation.
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DOI：
10.1016/j.tig.2016.03.005
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Iyer VR
中科院分区：
文献类型：
--
作者：
Bagchi DN;Iyer VR
近年来出现了一种新的范式，将转录起始描述为一个双向过程，包含了比以前认为的更大比例的基因组。过去的概念编码基因稀疏地分散在一个巨大的背景转录惰性非编码DNA已被抛弃。一个更丰富的图像已经形成，整合了编码基因，增强子RNA和各种其他非编码转录事件的转录。在这篇综述中，我们给出了一个概述，最近的研究详细的RNA聚合酶II为基础的转录启动机制，并讨论了转录方向的建立，以及其功能的影响。
A new paradigm has emerged in recent years characterizing transcription initiation as a bidirectional process, encompassing a larger proportion of the genome than previously thought. Past concepts of coding genes thinly scattered among a vast background of transcriptionally inert noncoding DNA have been abandoned. A richer picture has taken shape, integrating transcription of coding genes, enhancer RNAs, and various other noncoding transcriptional events. In this review we give an overview of recent studies detailing the mechanisms of RNA Pol II-based transcriptional initiation and discuss the ways in which transcriptional direction is established, as well as its functional implications.