Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect
Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect
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DOI：
10.1016/j.febslet.2005.07.085
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发表时间：
2005-09-12
期刊：
影响因子：
3.5
通讯作者：
Hartfelder, K
中科院分区：
文献类型：
--
作者：
Guidugli, KR;Nascimento, AM;Hartfelder, K
功能性不育的蜜蜂工蜂在执行巢任务时合成卵黄蛋白原。随后向觅食的转变与卵黄原蛋白的减少和幼年激素（JH）滴度的增加有关。JH是卵黄原蛋白表达和行为发育的主要控制者。然而，我们在这里表明，卵黄蛋白原表达的沉默导致JH滴度及其假定受体的显着增加。从数学上讲，这种增加对应于动态剂量反应。卵黄原蛋白在调节内分泌系统中的作用是不常见的，这可能解释了一个古老的生育调节途径如何被改造成一个控制社会行为的新回路。(c) 2005年欧洲生化学会联合会。Elsevier B.V.版权所有。
Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.