Relationships of serum estradiol levels, menopausal duration, and mood during hormonal replacement therapy
Relationships of serum estradiol levels, menopausal duration, and mood during hormonal replacement therapy
复制标题
DOI：
10.1016/s0306-4530(97)00043-7
复制
发表时间：
1997-10-01
影响因子：
3.7
通讯作者：
Snyder, MB
中科院分区：
文献类型：
--
作者：
Klaiber, EL;Broverman, DM;Snyder, MB
对38例绝经期妇女进行了周期性HRT（雌孕激素和雌孕激素+炔诺酮）研究。治疗期间血清雌二醇水平与情绪变化和血小板单胺氧化酶活性有关。血清雌二醇水平和情绪变化之间的关系被认为是绝经持续时间的函数。将绝经时间短的女性（12.9个月+/- 6.1）与绝经时间长的女性（76.6个月+/- 52.3）进行比较。与绝经时间长的女性相比，绝经时间短的女性在HRT期间的平均血清雌二醇水平显著较低（分别为216.9 +/- 62.3 vs. 291.13 +/- 118.12，p <0.02）。以前有报道说，雌激素治疗对更年期妇女的情绪有积极的影响，而雌激素加一种雌激素的组合对情绪有负面影响。我们发现，与绝经时间短、血清雌二醇水平较低的妇女相比，绝经时间长、血清雌二醇水平较高的妇女在接受雌激素加炔雌醇联合治疗时，烦躁不安的程度明显更高。然而，短期和长期绝经组显示情绪改善时，雌激素单独给药。血小板单胺氧化酶水平，肾上腺素能和肾上腺素能功能的标志物，被认为与情绪有关，在HRT期间与血清雌二醇水平呈负相关。我们认为，这些矛盾的发现可能是继发于长期的雌激素缺乏状态的妇女绝经期长。(C)1997年爱思唯尔科学有限公司
A study was undertaken in 38 menopausal women on cyclic HRT (estropipate and estropipate + norethindrone). Serum estradiol levels during treatment were related to mood changes and platelet MAO activity. The relationship between serum estradiol levels and mood changes was found to be a function of the duration of menopause. Women with a short duration of menopause (12.9 months +/- 6.1) were compared to women with a long duration of menopause (76.6 months +/- 52.3). Women with a short duration of menopause had significantly lower mean serum estradiol levels during HRT compared to women with a long duration of menopause (216.9 +/- 62.3 vs. 291.13 +/- 118.12, respectively, p < .02). It had previously been reported that estrogen treatment in menopausal women had a positive effect on mood, whereas the combination of estrogen plus a progestin had a negative effect on mood. We found that the women with a long duration of menopause and higher treatment serum estradiol levels had significantly more dysphoria when receiving a combination of estrogen plus progestin than did the women with a short duration of menopause and lower serum estradiol levels. However, both short and long duration menopausal groups showed improvement in mood when estrogen was administered alone. Platelet MAO levels, a marker of adrenergic and serotonergic function thought to relate to mood, were negatively correlated with serum estradiol levels during HRT. We suggest that these paradoxical findings may be secondary to a prolonged estrogen deficiency state in women with a long duration of menopause. (C) 1997 Elsevier Science Ltd.