Release of adenosine from rat lung by antigen and compound 48/80.
Release of adenosine from rat lung by antigen and compound 48/80.
复制标题
抗原和化合物 48/80 从大鼠肺中释放腺苷。
DOI：
10.1111/j.1748-1716.1981.tb06772.x
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
B. Fredholm
中科院分区：
文献类型：
--
作者：
B. Fredholm
茶碱抑制气道过敏性收缩的机制尚不清楚（Bowman &兰德1980）。其部分活性可能是由于抑制环核苷酸分解，部分是由于拮抗内源性腺苷，因为茶碱是治疗浓度药物中腺苷作用的强效抑制剂（Fredholm 1980）。已知腺苷可增强肥大细胞释放介质（马夸特等，1978; Fredholm & Sydbom，1980），并可拮抗茶碱的直接气管舒张作用（Fredholm等，1979）。我已经检查了肺能够释放腺苷的可能性，并且这种释放会因过敏性和假性过敏性反应而增强。
The mechanism by which theophylline inhibits anaphylactic constriction of the airways is not known (Bowman & Rand 1980). Part of its activity may be due to inhibition of cyclic nucleotide breakdown, part to antagonism of endogenous adenosine since theophylline is a potent inhibitor of adenosine actions in therapeutic concentrations of the drug (Fredholm 1980). Adenosine is known to potentiate mediator release from mast cells (Marquardt et al. 1978, Fredholm & Sydbom 1980) and it antagonizes the direct tracheorelaxant effect of theophylline (Fredholm et al. 1979). I have examined the possibility that lung is capable of releasing adenosine and that the release is enhanced by anaphylactic and pseudoanaphylactic reactions.