The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression.
The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression.
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NACHR和钙信号传导在胰腺癌开始和进展中的作用。
DOI：
10.3390/cancers7030845
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发表时间：
2015-07-31
期刊：
影响因子：
5.2
通讯作者：
Chellappan S
中科院分区：
文献类型：
--
作者：
Schaal C;Padmanabhan J;Chellappan S
胰腺癌与吸烟密切相关，目前的治疗策略在提高患者生存率方面相对无效。在过去的许多年里，人们一直在努力了解驱动胰腺癌发生和发展的分子事件，尤其是在吸烟的背景下。已经明确的是，烟草烟雾的成分不仅通过其诱变特性引发这些癌症，尤其是胰腺导管腺癌（PDAC），还可以通过刺激细胞增殖、血管生成、侵袭和上皮 - 间质转化来促进这些肿瘤的生长和转移。在细胞培养系统、动物模型和人类样本中的研究表明，烟碱型乙酰胆碱受体（nAChR）的激活通过多种途径传递信号来增强这些促肿瘤事件。在这种情况下，通过钙通道的信号传导似乎自身或在nAChR的下游促进胰腺癌的生长。这篇综述文章强调了nAChR下游信号事件和钙信号在胰腺癌的生长、转移以及耐药性中的作用。
Pancreatic cancer shows a strong correlation with smoking and the current therapeutic strategies have been relatively ineffective in improving the survival of patients. Efforts have been made over the past many years to understand the molecular events that drive the initiation and progression of pancreatic cancer, especially in the context of smoking. It has become clear that components of tobacco smoke not only initiate these cancers, especially pancreatic ductal adenocarcinomas (PDACs) through their mutagenic properties, but can also promote the growth and metastasis of these tumors by stimulating cell proliferation, angiogenesis, invasion and epithelial-mesenchymal transition. Studies in cell culture systems, animal models and human samples have shown that nicotinic acetylcholine receptor (nAChR) activation enhances these tumor-promoting events by channeling signaling through multiple pathways. In this context, signaling through calcium channels appear to facilitate pancreatic cancer growth by itself or downstream of nAChRs. This review article highlights the role of nAChR downstream signaling events and calcium signaling in the growth, metastasis as well as drug resistance of pancreatic cancer.