Nucleic acid-based methods for the detection of cancer
Nucleic acid-based methods for the detection of cancer
复制标题
DOI：
10.1126/science.278.5340.1054
复制
发表时间：
1997-11-07
期刊：
影响因子：
56.9
通讯作者：
Sidransky, D
中科院分区：
文献类型：
--
作者：
Sidransky, D
对推动癌症进展的遗传变化的持续阐明正在产生新的和潜在的强大的基于核酸的肿瘤疾病标记物。初步研究表明，这些标记物可用于在各种临床环境中以前所未有的精度检测癌细胞。基于核酸的标记物可能被证明是有价值的工具，用于早期检测无症状个体中的癌症，用于确认或排除基于可疑但非诊断性临床材料的癌症诊断，用于评估癌症患者的肿瘤负荷，以及用于评估对应用于处于发展癌症的高风险的健康个体的预防性方法的反应。这些标志物的例子，他们的潜在应用，以及目前的实际限制，他们的临床应用在这里进行审查。
Continued elucidation of the genetic changes that drive cancer progression is yielding new and potentially powerful nucleic acid-based markers of neoplastic disease. Pilot studies indicate that these markers can be used to detect cancer cells in a variety of clinical settings with unprecedented precision. Nucleic acid-based markers may prove to be valuable tools for early detection of cancer in asymptomatic individuals, for confirmation or exclusion of a cancer diagnosis that is based on suspicious but nondiagnostic clinical material, for assessment of tumor burden in cancer patients, and for assessment of response to preventive approaches applied to healthy individuals who are at high risk of developing cancer. Examples of these markers, their potential applications, and the current practical limitations on their clinical use are reviewed here.