Mathematical modeling of cardiac growth and remodeling.
Mathematical modeling of cardiac growth and remodeling.
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DOI：
10.1002/wsbm.1330
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Guccione JM
中科院分区：
文献类型：
--
作者：
Lee LC;Kassab GS;Guccione JM
本文综述了心脏生长和重构（G&R）数学模型的现状。我们简要地描述了与心脏G&R相关的实验观察结果，并讨论了描述这一过程的现有数学模型。为了便于讨论，我们根据(1)物理焦点（生化vs机械）和(2)它们描述的过程（肌细胞肥大vs细胞外基质重塑）组织了G&R模型。最后，对心脏G&R数学模型的发展方向进行了展望。
This review provides an overview of the current state of mathematical models of cardiac growth and remodeling (G&R). We concisely describe the experimental observations associated with cardiac G&R and discuss existing mathematical models that describe this process. To facilitate the discussion, we have organized the G&R models in terms of (1) the physical focus (biochemical vs. mechanical) and (2) the process that they describe (myocyte hypertrophy vs. extracellular matrix remodeling). The review concludes with a discussion of some possible directions that can advance the existing state of cardiac G&R mathematical modeling.