The methyltransferase SETD3-mediated histidine methylation: Biological functions and potential implications in cancers.
The methyltransferase SETD3-mediated histidine methylation: Biological functions and potential implications in cancers.
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DOI：
10.1016/j.bbcan.2020.188465
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Wen-Jie Shu;Hai-Ning Du
中科院分区：
文献类型：
--
作者：
Wen-Jie Shu;Hai-Ning Du
SETD3 belongs to a family of SET-domain containing proteins. Recently, SETD3 was found as the first and so-far the only known metazoan histidine methyltransferase that catalyzes actin histidine 73 (His73) methylation, a pervasive modification which was discovered more than 50 years ago. In this review, we summarize some recent advances in SETD3 research, focusing on structural properties, substrate-recognition features, and physiological functions. We particularly highlight potential pathological relevance of SETD3 in human cancers and raise some questions to promote discussion about this novel histidine methyltransferase.
