Measurement of recovery of function following whole muscle transfer, myoblast transfer, and gene therapy.
Measurement of recovery of function following whole muscle transfer, myoblast transfer, and gene therapy.
复制标题
全肌肉移植、成肌细胞移植和基因治疗后功能恢复的测量。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
R. Dennis
中科院分区：
文献类型：
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作者：
J. Faulkner;S. Brooks;R. Dennis
对于骨骼肌组织工程师来说，实验干预后最重要的问题是评估组织相对于对照组织的功能恢复情况。无论研究人员是通过自发(1)还是手术(2)血管和神经修复、成肌细胞移植(3)或操纵肌肉特异性基因（4,5）进行全肌肉移植，问题都是一样的：干预是损害、维持还是增强了相关骨骼肌的功能能力？在每种情况下，确定结构-功能关系至关重要，因为结构-功能关系在干预后经常被破坏，因此肌肉质量和总肌纤维横截面积（CSA）与控制值没有区别，但功能受损，或两者受损，但受损程度不同。
For a skeletal muscle tissue engineer, the most important issue following an experimental intervention is the evaluation of the recovery of the functional capabilities of the tissue, relative to those of the control tissue. Whether investigators perform whole muscle transfers with spontaneous (1) or surgical (2) vascular and nerve repair, myoblast transfers (3), or manipulations of muscle-specific genes (4,5), the question remains the same: Has the intervention impaired, maintained, or enhanced the functional capabilities of the skeletal muscles involved? In each case, determining structure-function relationships is of vital importance because structure-function relationships are frequently disrupted following an intervention, so that muscle mass and total muscle fiber cross-sectional area (CSA) are not different from control values, but function is impaired, or both are impaired, but with different magnitudes of impairment.
影响因子：
158.5
作者：
MENDELL, JR;KISSEL, JT;BURGHES, AHM
通讯作者：
BURGHES, AHM