Limb movement-induced hyperemia has a central hemodynamic component: evidence from a neural blockade study.
Limb movement-induced hyperemia has a central hemodynamic component: evidence from a neural blockade study.
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肢体运动引起的充血具有核心血流动力学成分：来自神经阻滞研究的证据。
DOI：
10.1152/ajpheart.00482.2010
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Richardson,RussellS
中科院分区：
文献类型：
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作者：
Trinity,JoelD;Amann,Markus;McDaniel,John;Fjeldstad,AnetteS;Barrett-O'Keefe,Zachary;Runnels,Sean;Morgan,DavidE;Wray,DWalter;Richardson,RussellS
本研究的目的是部分消除III/IV型骨骼肌传入的反馈，并确定这种反馈如何影响被动腿部运动的中枢和外周血流动力学反应。8名年轻男性在鞘内注射芬太尼之前和之后，在2 min被动伸膝期间测量心率（HR）、每搏输出量（SV）、心输出量（CO）、平均动脉压、腿部血管传导性（LVC）和腿部血流量（LBF）。被动运动使对照组（CON）的HR从基线增加14次/min（65 ± 4 ~ 79 ± 5次/min，P< 0.05），而芬太尼阻滞组（BLK）的HR没有显著增加。两种情况下LBF和LVC均增加;然而，这些增加在BLK期间减弱和延迟[从基线至最大值的变化%，LBF：CON 295 ± 109 vs. BLK 210 ± 86%，（P< 0.05）; LVC：CON 322 ± 40% vs. BLK 231 ± 32%，（P< 0.04）]。在CON中，HR、SV、CO和LVC增加有助于充血反应。然而，在BLK条件下，HR和SV的统计学上不显著的增加组合产生CO的小但显著的增加和减弱的充血反应。因此，部分阻断骨骼肌传入反馈会减弱被动肢体运动引起的中枢血流动力学反应，从而导致运动诱导的充血减弱和延迟。总之，这些发现提供了证据表明肢体运动诱导的充血具有由外周神经激活诱导的显著的中枢血流动力学成分。
The purpose of this investigation was to partially remove feedback from type III/IV skeletal muscle afferents and determine how this feedback influences the central and peripheral hemodynamic responses to passive leg movement. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure, leg vascular conductance (LVC), and leg blood flow (LBF) were measured during 2 min of passive knee extension in eight young men before and after intrathecal fentanyl injection. Passive movement increased HR by 14 beats/min from baseline to maximal response during control (CON) (65 ± 4 to 79 ± 5 beats/min,P< 0.05), whereas HR did not significantly increase with the fentanyl block (BLK). LBF and LVC increased in both conditions; however, these increases were attenuated and delayed during BLK [%change from baseline to maximum, LBF: CON 295 ± 109 vs. BLK 210 ± 86%, (P< 0.05); LVC: CON 322 ± 40% vs. BLK 231 ± 32%, (P< 0.04)]. In CON, HR, SV, CO, and LVC increased contributing to the hyperemic response. However, under BLK conditions, statistically insignificant increases in HR and SV combined to yield a small, but significant, increase in CO and an attenuated hyperemic response. Therefore, partially blocking skeletal muscle afferent feedback blunts the central hemodynamic response due to passive limb movement, which then results in an attenuated and delayed movement-induced hyperemia. In combination, these findings provide evidence that limb movement-induced hyperemia has a significant central hemodynamic component induced by peripheral nerve activation.