A synthetic peptide of human apoprotein E with antibacterial activity
A synthetic peptide of human apoprotein E with antibacterial activity
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DOI：
10.1016/s0196-9781(00)00165-0
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发表时间：
2000-03-01
期刊：
影响因子：
3
通讯作者：
Del Carpio, CA
中科院分区：
文献类型：
--
作者：
Azuma, M;Kojima, T;Del Carpio, CA
近年来，一些内源性哺乳动物抗菌肽已被描述。在许多情况下，两性阳离子α -螺旋是一个共同的特征；因此，其他具有这种特性的肽也可能具有抗生素活性。事实上，载脂蛋白E 133-162的一个30-mer肽（LRVRLASHLRKLRKRLLRDADDLQKRLAVY）被发现具有与经典抗生素（庆大霉素）和中性粒细胞来源的抗生素肽（CAP18）相当的抗生素活性。载脂蛋白E 133-162的阳离子性、疏水性和疏水力矩的计算以及螺旋轮图显示其与CAP18非常相似。(C) 2000 Elsevier Science Inc.；版权所有。
In recent years, several endogenous mammalian antibacterial peptides have been described. An amphipathic cationic alpha-helix is a common feature in many cases; therefore, other peptides with this characteristic might also possess antibiotic activity. In fact, a 30-mer peptide of apoprotein E 133-162 (LRVRLASHLRKLRKRLLRDADDLQKRLAVY) was found to have antibiotic activity comparable to those of a classic antibiotic (Gentamicin) and a neutrophil-derived antibiotic peptide (CAP18). Calculation of cationicity, hydrophobicity, and hydrophobic moment and the helical wheel diagram of apoprotein E 133-162 revealed close similarities to CAP18. (C) 2000 Elsevier Science Inc. All rights reserved.