A biobank to support HIV malignancy research for sub-Saharan Africa
A biobank to support HIV malignancy research for sub-Saharan Africa
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DOI：
10.7196/samj.2016.v106i9.10891
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发表时间：
2016-09-01
期刊：
影响因子：
--
通讯作者：
Silver, S
中科院分区：
文献类型：
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作者：
Schneider, J W;Sanderson, M;Silver, S
撒哈拉以南非洲是全球艾滋病毒感染率最高的地区之一，但由于获得抗逆转录病毒治疗的机会增加，该地区更多的人寿命延长。然而，沿着护理和治疗的增加，预计这一人群中与艾滋病毒相关的癌症将增加，正如在美国和其他发达国家所看到的那样。为了支持艾滋病毒相关癌症的转化研究，南非开普敦的Stellenbosch大学获得了资助，以容纳最先进的艾滋病和癌症标本资源撒哈拉以南非洲区域生物储存库（SSA RBR），以主动获取，管理和处理生物标本和相关临床数据，这些数据代表了艾滋病定义和非艾滋病定义的癌症。此外，撒哈拉以南非洲区域生物资源中心还充当艾滋病研究联盟在该区域开展撒哈拉以南非洲临床试验活动的生物储存库。虽然该中心在冷冻保存和储存标本方面有很多经验，但围绕国际环境和生物资源学会/国家癌症研究所最佳做法的运作，在保管与所有权、数据共享和设施管理等领域进行了能力建设。从选择到发射的过程历时14个月。
Sub-Saharan Africa has one of the highest incidences of infection with HIV globally, but more people in this region are living longer owing to increased access to antiretroviral therapy. However, along with increased care and treatment, this population is expected to have an increase in HIV-associated cancers, as is being seen in the USA and other developed countries. To support translational research in HIV-associated cancers, Stellenbosch University in Cape Town, South Africa, was funded to house the state-of-the-art AIDS and Cancer Specimen Resource Sub-Saharan Africa Regional Biorepository (SSA RBR) to proactively obtain, manage and process biospecimens and associated clinical data representing both AIDS-defining and non-AIDS-defining cancers for research. The SSA RBR furthermore functions as the biorepository for AIDS Malignancy Consortium sub-Saharan clinical trial activities in this region. Although the site had much experience with cryopreservation and storage of specimens, capacity building revolving around operations under International Society for Environmental and Biological Resources/National Cancer Institute best practices took place in such areas as custodianship v. ownership, data sharing and facilities management. The process from selection until launch took 14 months.