Systemic Chemotherapy in Metastasis-Induced Acute Pancreatitis Patients With Small Cell Lung Cancer
Systemic Chemotherapy in Metastasis-Induced Acute Pancreatitis Patients With Small Cell Lung Cancer
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转移性急性胰腺炎合并小细胞肺癌患者的全身化疗
DOI：
10.1097/mpa.0000000000001442
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发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
张双
中科院分区：
文献类型：
--
作者：
余敏;郑岭楠;韩德前;王永生;任莉;卢铀;张双
目的小细胞肺癌（SCLC）是一种高度恶性的肿瘤，其特征是在诊断时即发生早期转移。虽然胰腺转移发生在小细胞肺癌是一个常见的观察在文献中，目前有非常有限的经验，转移诱导急性胰腺炎的小细胞肺癌patients.MethodsHere我们回顾性分析了转移诱导急性胰腺炎和小细胞肺癌在华西医院2009年至2017年。患者通过支气管镜活检或计算机断层扫描引导下经皮穿刺活检诊断为SCLC。通过临床症状、放射学监测、血清淀粉酶和脂肪酶水平确定转移性胰腺炎。该系列包括14名患者，4名女性和10名男性，平均年龄为54岁（范围，29-76岁）。患者接受化疗加姑息治疗（n= 8）或姑息治疗单独（n= 6）。结果与接受姑息治疗的患者相比，改善生存的趋势观察到在患者谁经历chemotherapy.ConclusionOur个人经验表明，化疗可能会提供一个生存的好处，小细胞肺癌患者转移性胰腺炎，特别是那些具有良好的性能状态。
ObjectivesSmall cell lung carcinoma (SCLC) is a highly malignant tumor characterized by early metastasis even at the time of diagnosis. Although pancreatic metastasis occurring in SCLC is a common observation in the literatures, there is currently very limited experience with the metastasis-induced acute pancreatitis in SCLC patients.MethodsHere we retrospectively analyzed patients with metastasis-induced acute pancreatitis and SCLC in West China Hospital between 2009 and 2017. The patients were diagnosed as having SCLC by bronchoscopic biopsy or computed tomography–guided percutaneous biopsy. Metastasis-induced pancreatitis was established by clinical symptoms, radiologic surveillance, serum amylase, and lipase level. The series included 14 patients, 4 women and 10 men, with a mean age of 54 years (range, 29–76 years). The patients underwent chemotherapy plus palliative treatment (n= 8) or palliative care alone (n= 6).ResultsCompared with patients receiving palliative treatment alone, a trend toward improved survival was observed in patients who underwent chemotherapy.ConclusionOur personal experience indicated that chemotherapy might provide a survival benefit in SCLC patients with metastasis-induced pancreatitis, especially those with good performance status.